Corneal Cross-Linking: The Evolution of Treatment for Corneal Diseases. [PDF]
Front Pharmacol, 2021 Corneal cross-linking (CXL) using riboflavin and ultraviolet A (UVA) light has become a useful treatment option for not only corneal ectasias, such as keratoconus, but also a number of other corneal diseases.
Wu D +6 more
europepmc +7 more sources
Nanomedicine approaches for corneal diseases. [PDF]
J Funct Biomater, 2015 Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions.
Chaurasia SS +3 more
europepmc +6 more sources
The role of lipids in corneal diseases and dystrophies: a systematic review. [PDF]
Clin Transl Med, 2017 Corneal diseases are an extensive cause of blindness worldwide and continue to persist as a challenging public health concern. Recently, various lipid-based therapies have been advocated for the modulation of corneal diseases; however, the number of ...
Rowsey TG, Karamichos D.
europepmc +4 more sources
Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift. [PDF]
Eye Vis (Lond), 2023 Different diagnostic approaches for ectatic corneal diseases (ECD) include screening, diagnosis confirmation, classification of the ECD type, severity staging, prognostic evaluation, and clinical follow-up.
Ambrósio R +9 more
europepmc +2 more sources
Cell Therapy of Corneal Diseases. [PDF]
Cornea, 2016 Mesenchymal stem cells isolated from connective tissues are pluripotent and differentiate into phenotypes of connective tissue cell lineages (osteoblasts, chondrocytes, and adipocytes) in vitro and in vivo. They have been used to treat mouse models of connective tissue disease such as lumican-null (Lum) and mucopolysaccharidosis (Gusb) mice ...
Kao WW, Coulson-Thomas VJ.
europepmc +5 more sources
Mesenchymal Stem Cells and Exosomes: A Novel Therapeutic Approach for Corneal Diseases. [PDF]
Int J Mol Sci, 2023 The cornea, with its delicate structure, is vulnerable to damage from physical, chemical, and genetic factors. Corneal transplantation, including penetrating and lamellar keratoplasties, can restore the functions of the cornea in cases of severe damage ...
Bhujel B +8 more
europepmc +2 more sources
Metabolomics in Corneal Diseases: A Narrative Review from Clinical Aspects. [PDF]
Metabolites, 2023 Corneal pathologies may have subtle manifestations in the initial stages, delaying diagnosis and timely treatment. This can lead to irreversible visual loss.
Teo AWJ, Zhang J, Zhou L, Liu YC.
europepmc +2 more sources
Big data in corneal diseases and cataract: Current applications and future directions. [PDF]
Front Big Data, 2023 The accelerated growth in electronic health records (EHR), Internet-of-Things, mHealth, telemedicine, and artificial intelligence (AI) in the recent years have significantly fuelled the interest and development in big data research.
Ting DSJ, Deshmukh R, Ting DSW, Ang M.
europepmc +2 more sources
Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives. [PDF]
J Ophthalmol, 2022 Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases,
Lin W, Chen M, Cissé Y, Chen X, Bai L.
europepmc +2 more sources
Methylation in cornea and corneal diseases: a systematic review. [PDF]
Cell Death DiscovCorneal diseases are among the primary causes of blindness and vision loss worldwide. However, the pathogenesis of corneal diseases remains elusive, and diagnostic and therapeutic tools are limited.
Xia Y +11 more
europepmc +2 more sources