Results 21 to 30 of about 90,437 (193)

Advances and challenges of CRISPR/Cas gene editing for corneal diseases. [PDF]

Adv Ophthalmol Pract Res
Background: Corneal diseases are a major cause of global visual impairment, and current treatments remain inadequate for severe or refractory cases. The CRISPR/Cas system offers robust and precise gene-editing capabilities, yet its therapeutic potential ...
Han Y, Chen R, Shentu X.
europepmc   +2 more sources

Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis [PDF]

, 2011
Background: Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6(+/-) heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal ...
Fullwood, Nigel J., Martin, Francis L., Collinson, J. Martin, Richard L Mort, Morley, Steven D., Morley Steven D., West John D., Bentley, Adam J., Adam J Bentley, Mort, Richard L, Collinson J. Martin, Panagiotis Douvaras, Collinson, J Martin, J Martin Collinson, Bentley Adam J., Mort Richard L., Martin, Francis L, Bentley, Adam J, Morley, Steven D, Martin Francis L., Douvaras, Panagiotis, Steven D Morley, Robert E Hill, Mort, Richard L., West, John D., Hill, Robert E, Fullwood, Nigel J, Nigel J Fullwood, Douvaras Panagiotis, Fullwood Nigel J., Francis L Martin, Hill Robert E., Hill, Robert E., West, John D, John D West   +34 more
core   +1 more source

In vivo confocal microscopy qualitative investigation of the relationships between lattice corneal dystrophy deposition and corneal nerves

BMC Ophthalmology, 2021
Background To investigate the corneal neurotropic phenomenon in patients with lattice corneal dystrophy (LCD) with in vivo laser scanning confocal microscopy (IVCM).
Fengjiao Zhu, Ming Li, Chun Zhang, Chan Chen, Fangwei Ying, Danyao Nie   +5 more
doaj   +1 more source

Corneal diseases of rabbits

Veterinary Clinics of North America: Exotic Animal Practice, 2002
Corneal diseases are common in domestic rabbits. It is important to carefully evaluate the cornea and the entire eye when rabbit present with clinical signs such as squinting, tearing, or conjunctival hyperemia. Complete ophthalmic examination and general physical examination should be performed on all rabbits with corneal disease. Important diagnostic
Department of Comparative Ophthalmology, Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, FL 32610-0126, USA ( host institution ), Andrew, Stacy E   +1 more
openaire   +3 more sources

In Vivo Confocal Microscopic Corneal Images in health and disease with an emphasis on extracting features and visual signatures for corneal diseases: A review study [PDF]

, 2015
There is an evolution in the demands of modern ophthalmology from descriptive findings toassessment of cellular level changes by using in vivo confocal microscopy. Confocal microscopy,by producing grey-scale images, enables a microstructural insight into
Brahma, Arun, Alzubaidi, Rania, Ipson, Stanley, Sharif, Saeed, Qahwaji, Rami   +4 more
core   +1 more source

Factors Governing Photodynamic Cross-Linking of Ocular Coat [PDF]

, 2011
This thesis addresses the challenge of minimizing toxicity of therapeutic protein-protein cross-linking of the cornea and sclera. Protein-protein cross-links include disulfide bonds, enzymatic cross-links and non-enzymatic cross-links.
Huynh, Joyce
core   +1 more source

Eccentric lamellar keratolimbal grafts harvested with a manually guided microkeratome [PDF]

, 2007
Background: To perform lamellar keratolimbal allograft transplantation in a one- step procedure with a single graft, we investigated the feasibility of harvesting eccentric lamellar keratolimbal grafts from conventionally processed corneoscleral buttons ...
Priglinger, Siegfried G., Lackerbauer, Carlo, Grueterich, Martin, Welge-Luessen, Ulrich, Kampik, Anselm, Kenyon, Kenneth R.   +5 more
core   +1 more source

The clinicopathological analysis of ocular and orbit tumors in southeast of China

Frontiers in Oncology, 2023
PurposeThe purpose of this study is to describe the clinicopathologic characteristics of ocular surface and orbit tumors in the Southeast of China and explore the method to differentiate the benign and malignant masses.Materials and methods3468 patients ...
Yuan Lin, Yuan Lin, Xiaodong Liu, Xiaodong Liu, Yujie Zhang, Yujie Zhang, Zhiwen Xie, Zhiwen Xie, Xie Fang, Xie Fang, Ke Shi, Ke Shi, Yanlin Zhong, Yanlin Zhong, Shengqi Su, Shengqi Su, Shengqi Su, Minqing Cai, Minqing Cai, Huping Wu, Huping Wu, Shangkun Ou, Shangkun Ou   +22 more
doaj   +1 more source

Expression of TSLP and Downstream Molecules IL-4, IL-5, and IL-13 on the Eye Surface of Patients with Various Types of Allergic Conjunctivitis

Journal of Ophthalmology, 2016
Background. The pathogenesis of allergic conjunctivitis has not been clearly established. Moreover, previous studies fail to consider human models of allergic conjunctivitis.
Xiaofen Zheng, Juan Yao, Bing Li
doaj   +1 more source

Current Trends and Future Perspective of Mesenchymal Stem Cells and Exosomes in Corneal Diseases [PDF]

International Journal of Molecular Sciences, 2019
Hassan Mansoor, Shing Ong, Andrí K Riau   +2 more
exaly   +2 more sources