Results 11 to 20 of about 2,380,494 (206)

Methylation in cornea and corneal diseases: a systematic review [PDF]

Cell Death Discovery
Corneal diseases are among the primary causes of blindness and vision loss worldwide. However, the pathogenesis of corneal diseases remains elusive, and diagnostic and therapeutic tools are limited.
Yutong Xia, Kuangqi Chen, Qianjie Yang, Zhitong Chen, Le Jin, Liyue Zhang, Xin Yu, Liyin Wang, Chen Xie, Yuan Zhao, Ye Shen, Jianping Tong   +11 more
doaj   +3 more sources

Corneal Disease & Transplantation [PDF]

Journal of Clinical Medicine, 2022
Corneal diseases represent the third leading cause of blindness worldwide, and corneal transplantation, which aims at restoring corneal clarity and vision, is the most frequently performed transplant worldwide [...]
Giulia Coco, Vito Romano
openaire   +6 more sources

Nanomedicine Approaches for Corneal Diseases [PDF]

Journal of Functional Biomaterials, 2015
Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions. However, barrier properties of the ocular surface necessitate high concentration of the drugs applied in the eye ...
Shyam Chaurasia, Rayne Lim, Rajamani Lakshminarayanan, Rajiv Mohan   +3 more
openaire   +4 more sources

Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives. [PDF]

J Ophthalmol, 2022
Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases,
Lin W, Chen M, Cissé Y, Chen X, Bai L.
europepmc   +2 more sources

Advances and challenges of CRISPR/Cas gene editing for corneal diseases. [PDF]

Adv Ophthalmol Pract Res
Background: Corneal diseases are a major cause of global visual impairment, and current treatments remain inadequate for severe or refractory cases. The CRISPR/Cas system offers robust and precise gene-editing capabilities, yet its therapeutic potential ...
Han Y, Chen R, Shentu X.
europepmc   +2 more sources

Adeno-Associated Virus Mediated Gene Therapy for Corneal Diseases. [PDF]

Pharmaceutics, 2020
According to the World Health Organization, corneal diseases are the fourth leading cause of blindness worldwide accounting for 5.1% of all ocular deficiencies. Current therapies for corneal diseases, which include eye drops, oral medications, corrective
Bastola P, Song L, Gilger BC, Hirsch ML.
europepmc   +2 more sources

Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis [PDF]

, 2011
Background: Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6(+/-) heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal ...
Fullwood, Nigel J., Martin, Francis L., Collinson, J. Martin, Richard L Mort, Morley, Steven D., Morley Steven D., West John D., Bentley, Adam J., Adam J Bentley, Mort, Richard L, Collinson J. Martin, Panagiotis Douvaras, Collinson, J Martin, J Martin Collinson, Bentley Adam J., Mort Richard L., Martin, Francis L, Bentley, Adam J, Morley, Steven D, Martin Francis L., Douvaras, Panagiotis, Steven D Morley, Robert E Hill, Mort, Richard L., West, John D., Hill, Robert E, Fullwood, Nigel J, Nigel J Fullwood, Douvaras Panagiotis, Fullwood Nigel J., Francis L Martin, Hill Robert E., Hill, Robert E., West, John D, John D West   +34 more
core   +5 more sources

Early Visibility of Cellular Aggregates and Changes in Central Corneal Thickness as Predictors of Successful Corneal Endothelial Cell Injection Therapy

Cells, 2023
(1) Background: Cell injection therapy is an emerging treatment for bullous keratopathy (BK). Anterior segment optical coherence tomography (AS-OCT) imaging allows the high-resolution assessment of the anterior chamber. Our study aimed to investigate the
Evan N. Wong, Valencia H. X. Foo, Gary S. L. Peh, Hla M. Htoon, Heng-Pei Ang, Belinda Y. L. Tan, Hon-Shing Ong, Jodhbir S. Mehta   +7 more
doaj   +1 more source

Advances in clinical examination of lacrimal gland

Frontiers in Medicine, 2023
In humans, the lacrimal gland is located in the socket of the frontal bone above the outer orbital area. As an essential part of the eye surface, the gland is fixed to the orbital periosteum by connective tissue.
Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yujie Zhang, Yujie Zhang, Yujie Zhang, Yujie Zhang, Ke Shi, Ke Shi, Ke Shi, Ke Shi, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Shangkun Ou, Shangkun Ou, Shangkun Ou, Shangkun Ou, Shangkun Ou   +20 more
doaj   +1 more source

The Effects of Donor-Recipient Age and Sex Compatibility in the Outcomes of Deep Anterior Lamellar Keratoplasties

Frontiers in Medicine, 2022
PurposeCorneal transplantations are the commonest allogenic transplant surgeries performed worldwide. Transplantable grade donor cornea is a finite resource.
Hon Shing Ong, Hon Shing Ong, Hon Shing Ong, Nathalie Chiam, Hla Myint Htoon, Hla Myint Htoon, Ashish Kumar, Anshu Arundhati, Anshu Arundhati, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta   +12 more
doaj   +1 more source