Results 91 to 100 of about 9,329,954 (313)

Double gene mutations of LRSAM1 and REEP1 and a new REEP1 mutation site found in a patient with amyotrophic lateral sclerosis with subjective paresthesia: A case report

Ibrain, EarlyView., 2023
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. Leucine‐rich repeats and sterility α mutations in motif 1 (LRSAM1) has been proven to be involved in the pathogenesis of ALS.
Ji‐Yao Qin, Zun‐Lin Zhou, Yuan‐Qing Zhou, Ya Chen, Xiao‐Yan Yang, Hai‐Qing Zhang, Zu‐Cai Xu   +6 more
wiley   +1 more source

Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases

Journal of Ophthalmology, 2017
ROCK (Rho kinase) signaling regulates a wide spectrum of fundamental cellular events and is involved in a variety of pathological conditions. It has therefore attracted research interest as a potential therapeutic target for combating various diseases ...
Naoki Okumura, S. Kinoshita, N. Koizumi
semanticscholar   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases

Human Molecular Genetics, 2013
Three genetic corneal dystrophies [congenital hereditary endothelial dystrophy type 2 (CHED2), Harboyan syndrome and Fuchs endothelial corneal dystrophy] arise from mutations of the SLC4a11 gene, which cause blindness from fluid accumulation in the ...
Gonzalo L. Vilas, S. Loganathan, Jun Liu, A. Riau, J. Young, J. Mehta, E. Vithana, J. Casey   +7 more
semanticscholar   +1 more source

A Tailored Artificial Biocatalyst for Bacterial Endophthalmitis Therapy via Enhanced Ferroptosis‐Like Death

Advanced Science, EarlyView.
A tailored bio‐targeted catalytic strategy based on a bacteria‐specific artificial biocatalyst (MoS2/Fe@mercaptophenylboronic acid@hyaluronic acid, MFBH) is proposed for treating bacterial endophthalmitis. This strategy exhibits high‐efficiency peptidoglycan‐targeted bactericidal efficacy in vivo following a single intravitreal injection of an ...
Caixia Sun, Yingying Jiang, Shibo Zhang, Zhipeng Ding, Lijun Pu, Xinmei Liu, Jun Yang, Xiangkai Zhuge, Jianjun Dai, Yanmin Ju   +9 more
wiley   +1 more source

Comparison of Outcomes between Endoscopic and Transcleral Cyclophotocoagulation. [PDF]

, 2017
Importance: Traditionally cyclophotocoagulation has been reserved as a treatment of last resort for eyes with advanced stage glaucoma, but increasingly it is offered to eyes with less severe disease.
Beardsley, Robert, Caprioli, Joseph, Coleman, Anne L, Giaconi, JoAnn A, Hubschman, Jean-Pierre, Law, Simon K, Nouri-Mahdavi, Kouros, Schwartz, Steven D   +7 more
core   +3 more sources

Corneal Biomechanics in Ectatic Diseases: Refractive Surgery Implications

Open Ophthalmology Journal, 2017
Background: Ectasia development occurs due to a chronic corneal biomechanical decompensation or weakness, resulting in stromal thinning and corneal protrusion. This leads to corneal steepening, increase in astigmatism, and irregularity.
Renato Ambrósio Jr., F. F. Correia, Bernardo T. Lopes, Marcella Q. Salomão, Allan Luz, D. Dawson, A. Elsheikh, R. Vinciguerra, P. Vinciguerra, C. Roberts   +9 more
semanticscholar   +1 more source

BMSC‐NFMC Model for Vascular Regulation and Interface Integration in Osteochondral Regeneration

Advanced Science, EarlyView.
A novel strategy for integrated osteochondral tissue regeneration using BMSC‐NFMCs, this study has demonstrated the precise regulation of vascularization and effective interface integration using optimized nanofibrous materials and innovative construction methods.
Qian Zhou, Mengjie Hou, Baoshuai Bai, Yiwu Zhang, Yiwei Shen, Zenghui Jia, Yongqiang Guo, Guangdong Zhou, Xiaoqin Liang   +8 more
wiley   +1 more source

Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature

Clinical Ophthalmology, 2016
Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to strengthen corneal tissue reforming new covalent bonds.
L. Spadea, E. Tonti, E. Vingolo
semanticscholar   +1 more source

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia

Advanced Science, EarlyView.
Plasma metabolic detection combined with machine learning offers a precise (area under the curve of 0.874) and high‐throughput (<30 s) diagnosis for pathologic myopia (serious myopic macular degeneration). The biomarkers indicate the pathologic myopia‐associated systemic metabolic reprogramming, which exhibits specificity for myopic macular ...
Ziheng Qi, Jiao Qi, Ye Zhang, Yanhui Wang, Yuchen Feng, Zifan Yang, Yating Wang, Weikang Shu, Dongling Guo, Ching Kang, Keke Zhang, Yi Lu, Jingjing Wan, Xiangjia Zhu   +13 more
wiley   +1 more source