Results 91 to 100 of about 135,122 (302)

Recommendations for the management of MPS VI: systematic evidence- and consensus-based guidance. [PDF]

, 2019
IntroductionMucopolysaccharidosis (MPS) VI or Maroteaux-Lamy syndrome (253200) is an autosomal recessive lysosomal storage disorder caused by deficiency in N-acetylgalactosamine-4-sulfatase (arylsulfatase B).
Akyol, Mehmet Umut, Alden, Tord D, Amartino, Hernan, Ashworth, Jane, Belani, Kumar, Berger, Kenneth I, Borgo, Andrea, Braunlin, Elizabeth, Eto, Yoshikatsu, Giugliani, Roberto, Gold, Jeffrey I, Harmatz, Paul, Hendriksz, Christian, Jester, Andrea, Jones, Simon A, Karsli, Cengiz, Mackenzie, William, Marinho, Diane Ruschel, McFadyen, Andrew, McGill, Jim, Mitchell, John J, MPS Consensus Programme Co-Chairs, MPS Consensus Programme Steering Committee, Muenzer, Joseph, Okuyama, Torayuki, Orchard, Paul J, Scarpa, Maurizio, Stevens, Bob, Thomas, Sophie, Walker, Robert, Wynn, Robert   +30 more
core  

Tear ferning test and pathological effects on ocular surface before and after topical cyclosporine in vernal keratoconjunctivitis patients [PDF]

, 2018
Background: Vernal keratoconjunctivitis (VKC) is a rare ocular surface inflammatory disease that affects mainly boys in the first decade of life.
Bianchi, Guia, Del Regno, Paola, Duse, Marzia, Lambiase, Alessandro, Nebbioso, Marcella, Sacchetti, Marta, Zicari, Anna Maria   +6 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

The bidirectional enigma of glaucoma and anxiety: from neuroinflammatory mechanisms to mind-body integrated therapies

Frontiers in Psychiatry
IntroductionGlaucoma, a leading cause of irreversible global blindness, has a bidirectional association with anxiety that worsens both conditions. Anxiety prevalence in glaucoma patients (19.07%–25.71%) is much higher than the general population’s 9.8 ...
Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Jing Tang, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li   +18 more
doaj   +1 more source

Matrix Metalloproteinases and Glaucoma Treatment. [PDF]

, 2020
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in ...
Dibas, Mohammed, Robinson, Michael R, Stamer, W Daniel, Weinreb, Robert N   +3 more
core  

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Ion‐Pair‐Tuned Ionogels for Broad‐Range Linear Pressure Sensing

Advanced Science, EarlyView.
Ionogels engineered through ion‐pair tuning extend the linear sensing range of capacitive pressure sensors. By balancing ionic mobility and polarizability within the polymer matrix, this approach mitigates dielectric saturation and maintains a stable pressure response across a broad operating range.
Hyeonseo Joo, Tianhao Yu, Yumin Dai, Seokkyoon Hong, Axel González Cornejo, Tristan Michael Long, Sang Mok Park, Pete S. Kollbaum, Edgar Bolívar‐Nieto, Young L. Kim, Dong Rip Kim, Chi Hwan Lee   +11 more
wiley   +1 more source

Risk factors for recurrence of Mooren's ulcer after keratoplasty

Heliyon
Purpose: The purpose of this study was to investigate the clinical characteristics of patients with corneal Mooren's ulcers (MU) and explore potential risk factors for recurrence after keratoplasty. Methods: The study retrospectively analyzed 87 patients
Shangkun Ou, Yujie Zhang, Yuan Lin, Xie Fang, Zhiwen Xie, Ke Shi, Minqing Cai, Shengqi Su, Huping Wu   +8 more
doaj   +1 more source

Soft and Adhesive Cardiac Patch for Electrophysiological and Contraction Measurement

Advanced Science, EarlyView.
This study developed an epicardial electronic patch with a modulus similar to that of the heart (approximately 65kPa), which can collect stable electrocardiogram signals and myocardial contractility on the surface of a dynamically beating heart. This is attributed to the hydrogen bond interaction formed between the amino and catechol groups in the ...
Wuliang Chen, Xinyu Shen, Hanning Liu, Lamei Du, Caicai Jiao, Longfei Li, Qian Wang, Qiuting Zhang, Lixue Tang, Liang Hu, Yubo Fan   +10 more
wiley   +1 more source

Correlations between tear lymphocytotoxin-a (LT-α) level and disease severity in adult keratoconus

Frontiers in Medicine
PurposeThis study aimed to investigate tear lymphocytotoxin-α (LT-α) levels in adult keratoconus patients and identify the correlations between LT-α and the disease severity of keratoconus.MethodsIn this cross-sectional study, tear samples from 100 ...
Xiuxian Qin, Xiuxian Qin, Shunrong Luo, Xie Fang, Xianwen Xiao, Zhiwen Xie, Xumin Shang, Juan Yang, Xi Lan, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Zhirong Lin, Zhirong Lin, Zhirong Lin, Zhirong Lin, Zhirong Lin, Zhirong Lin   +20 more
doaj   +1 more source