Results 61 to 70 of about 68,439 (196)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Medication Adherence Among Patients With Corneal Diseases. [PDF]

Cornea, 2021
Khan M, Michelson S, Newman-Casey PA, Woodward MA.   +3 more
europepmc   +1 more source

Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting‐Edge Antioxidants

Global Challenges, EarlyView.
This review has systematically evaluated the oxidative damage of cornea, tear film, lacrimal gland, conjunctiva and meibomian gland for dry eye, and concluded the antioxidants that are either commercially available or in the research phase. GQDs: Graphene quantum dots; LF: lactoferrin; ROS: Reactive oxygen species; SOD: Superoxide dismutase; tFNA ...
Rong Hu, Jian Shi, Can‐Ming Xie, Xiao‐Lei Yao   +3 more
wiley   +1 more source

Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives. [PDF]

J Ophthalmol, 2022
Lin W, Chen M, Cissé Y, Chen X, Bai L.
europepmc   +1 more source

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, EarlyView.
Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source

Culture and characterization of canine and feline corneal epithelial organoids: A new tool for the study and treatment of corneal diseases. [PDF]

Front Vet Sci, 2022
Bedos L, Wickham H, Gabriel V, Zdyrski C, Allbaugh RA, Sahoo DK, Sebbag L, Mochel JP, Allenspach K.   +8 more
europepmc   +1 more source

Keratoconus; a true corneal disease

Journal of Ophthalmic and Vision Research, 2016
Navid Ghassembaglou, Ali R. Djalilian
openaire   +3 more sources

Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Madison Owens, Anita Thyagarajan, Jeffrey B. Travers, Ravi P. Sahu   +3 more
wiley   +1 more source

Results of the Pinhole Test Correlate with Hybrid Contact Lens Visual Acuity in Patients with Visual Impairment due to Corneal Diseases. [PDF]

J Ophthalmol, 2022
Kanclerz P.
europepmc   +1 more source

Microsaccades Tracking by Secondary Speckle Pattern Analysis

Journal of Biophotonics, EarlyView.
A new approach for detecting microsaccades is introduced using secondary speckle patterns reflected from the sclera. This method offers potential benefits in capturing subtle eye movements and overcoming limitations in traditional pupil‐tracking systems.
Ola Shteinberg, Sergey Agdarov, Yafim Beiderman, Yoram S. Bonneh, Inbal Ziv, Zeev Kalyuzhner, Zeev Zalevsky   +6 more
wiley   +1 more source