Results 61 to 70 of about 86,560 (256)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Myo-inflam: a mini review on inflammatory pathways driving scleral remodeling and axial elongation

Frontiers in Immunology
Myopia has become a global public health challenge, with pathological high myopia leading to irreversible visual impairment. Accumulating evidence suggests that chronic inflammation is closely associated with scleral remodeling and axial elongation, the ...
Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Wei Liang, Li-rong Cai, Li-rong Cai, Li-rong Cai, Li-rong Cai, Li-rong Cai, Li-rong Cai, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li   +29 more
doaj   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Visual outcomes and spectacle independence of a non-diffractive wavefront-shaping intraocular lens in post-LASIK patients

Frontiers in Medicine
PurposeTo compare visual outcomes, depth of field (DOF), spectacle independence, and patient satisfaction of cataract patients with and without previous myopic laser in situ keratomileusis (LASIK) surgery who received a non-diffractive extended range-of ...
Wei Fan, Wei Fan, Wei Fan, Wei Fan, Wei Fan, Wei Fan, Meiyi Zhu, Meiyi Zhu, Meiyi Zhu, Meiyi Zhu, Meiyi Zhu, Meiyi Zhu, Guangbin Zhang, Guangbin Zhang, Guangbin Zhang, Guangbin Zhang, Guangbin Zhang, Guangbin Zhang   +17 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Case Report: Novel FOXC1 variant c.311T>G (p.Ile104Ser) in a Chinese family with Axenfeld-Rieger syndrome

Frontiers in Medicine
BackgroundJuvenile-onset open-angle glaucoma (JOAG) is a heterogeneous early-onset glaucoma subtype. Axenfeld-Rieger syndrome (ARS) is an autosomal dominant disorder caused by FOXC1 variants, which may present with severe early-onset glaucoma and can be ...
Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Li Li, Li Li, Li Li, Li Li, Li Li, Li Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li   +17 more
doaj   +1 more source

Corneal reflex in hemisphere disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1972
The contralateral corneal reflex may be absent in patients with a deep lesion of the parietal lobe. Frontal and temporal lobe lesions apparently do not interfere with this reflex.
openaire   +2 more sources

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Perioperative nursing outcomes and management strategies in cold plasma ablation for superficial corneal disorders

Frontiers in Surgery
ObjectiveTo evaluate the clinical outcomes and perioperative nursing outcomes of low-temperature plasma ablation (LTPA) for the treatment of superficial corneal diseases.MethodsThis retrospective study analyzed 38 patients who underwent LTPA between June
Dan Hu, Dan Hu, Dan Hu, Dan Hu, Dan Hu, Dan Hu, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu   +17 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source