Results 31 to 40 of about 97,726 (210)

New Frontier in the Management of Corneal Dystrophies: Basics, Development, and Challenges in Corneal Gene Therapy and Gene Editing

, 2022
Corneal dystrophies represent a group of heterogeneous hereditary disorders causing progressive corneal opacification and blindness. Current corneal transplant management for corneal dystrophies faces the challenges of repeated treatments, complex ...
Sunita Chaurasia, Anshuman Verma, Deepak Kumar Sahel, Salman, Mohd, Jilu Jaffet, Singh, Vijay Kumar, Mohd Salman, Vijay Kumar Singh, Muralidhar Ramappa, Vivek Singh, Verma, Anshuman, Jaffet, Jilu   +11 more
core   +1 more source

IC3D classification of corneal dystrophies-edition 2

, 2015
Purpose: To update the 2008 International Classification of Corneal Dystrophies (IC3D) incorporating new clinical, histopathologic, and genetic information.
Kenyon, K.R., Weiss, Jayne S., Lisch, Walter, Munier, F.L., Kim, E.K., Kenyon, Kenneth R., Rapuano, C.J., Lisch, W., Sutphin, John, Kivelä, T., Kinoshita, S., Rapuano, Christopher J., Mà ̧ller, Hans Ulrik, Kim, Eung Kweon, Bredrup, C., Aldave, A.J., Kinoshita, Shigeru, Aldave, Anthony J., Labbé, A., Seitz, Berthold, Bredrup, Cecilie, Nischal, K.K., Møller, H.U., Busin, Massimo, Nischal, Kanwal K., Seitz, B., Busin, M., Munier, Francis L., Sutphin, J., Weiss, J.S., Labbé, Antoine, Kivelä, Tero   +31 more
core   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Optimal Resources for Children's Surgery 2: Tiered Recommendations for Minimum Essential Children's Surgical Procedures Across Health System Levels

World Journal of Surgery, EarlyView.
In 2015 the World Health Assembly (WHO), based on recommendations by the Lancet Commission on Global Surgery, passed resolution (68:15) on strengthening emergency and essential surgical care and anesthesia as a component of universal health coverage. However, children's surgery was not adequately represented and in response, the Global Initiative for ...
Arpita Biswangree, Emmanuel A. Ameh, Kokila Lakhoo, Mohamed Shalaby, Sarah Beth Cairo, on behalf of GICS Membership, Abdelhafeez Hafeez, Dayang A Abdul Aziz, Abdur‐Rahman Lukman Olajide, Simone Abib, Mohammed J. Aboud, Abu Bakr Abdullah Adam Amal, Maimuna Abubakar, Piero Ali Alberti, Abdelbasit Elsayed, Abdullah Mohd Yusof, Abellar Hilda, Acharya Utsav, Amaraegbulam Peace Ifeoma, Amde Samuel Negash, Antoine Seraphin Gbenou, Arca Marjorie, Axt Jason, Banu Tahmina, Bezuhly Michael, Biswangree Arpita, Marilyn W. Butler, Michael Buzuhly, Sarah B. Cairo, Juan Francisco Campos Rodezno, Maija Cheung, Chirdan Lohfa, Milind Chitnis, Zachary Clapp, Hannah Cockrell, Aline Coltro, Deshpande Gaurav, Diao Mei, Donou Amivi Alice, Beda Espineda, Faye M. Evans, Ewnte Biniam, Fadhili Bake Jacques, Faktor Kara, Farmer Diana Lee, Gaffar Ilijana, Ganey Michael, Gathuya Zipporah, J. F. Gonzalez‐Zamora, Christa N. Grant, Gray Rebecca Crane, Hasnaien Ahmed, Hettiarachchi Mathula, Hsu Phillip, Ibrahim Rahma Wala Mohammed, Romeo C. Ignacio, Inglin Sophie, Islam Saleem, Kageni Maina Reuel, Kengo Nathan Ezie, Kisa Phyllis, Lakhoo Kokila, Langer Monica, Leodoro Basil, Lindert Judith, Lobos Pablo Andrés, Løfberg Katrine, Madhuri Vrisha, Martin Yturralde Erick, Mazingi Dennis, Mcleod Elizabeth Jane, John G. Meara, Felicity Vidya Mehendale, Felicity Vidya Mehendale, Milano Leecarlo, Hanifah N. A. Mohd, Moreno Amabelle, Mpongo Yves, Mrutu Salehe, Muthumani Abirami, Nah Shireen Anne, Naik‐Mathuria Bindi, Nandi Biplab, Ramesh M. Nataraja, Newton Odongo Charles, Nimanya Stella Alice, Nixon Cathrine, Ntegerejuwampaye Angélique, Obi Nkeiruka, Obisesan Aderonke Omoyeni, Odera Agneta, Ondima Lucienne Irene Patricia, Maryrose O. Osazuma, Owusu Ofori Emmanuel, Ozgediz Doruk, Pacheco Cesar Hector Alberto, Patel Nirav, Peer Shazia, Phelps Janey, Pilkington Mercedes, Poenaru Dan, Ravindran Vinitha, Rolle Udo, Saldaña Gallo Lily, Saleh Abdullah, Samad Lubna, Sedano Sabrina, Sethi Bijaya Kumar, Justina Seyi‐Olajide, Shalaby Mohamed Sameh, Sharma Mehek, Siddiqui Sabina, Stephens Caroline, Stoltz Judith, Talat Nabila, Warwick J. Teague, Tekant Gonca, Tumba Kapaso Nadyn, Wildhaber Barbara, Ava C. Yap, Zanon Nelci, Zope Madhushree   +121 more
wiley   +1 more source

Challenges in the complex management of post-keratoplasty glaucoma

Therapeutic Advances in Ophthalmology, 2021
Glaucoma is a serious complication after corneal transplantation and itself a common cause for graft failure and leading cause of vision loss post-keratoplasty due to corneal endothelial decompensation.
Lisa-Marie Anders, Zisis Gatzioufas, Matthias C. Grieshaber   +2 more
doaj   +1 more source

Reduced quality of life in corneal dystrophy – a prospective case control study

BMC Ophthalmology
Background Corneal dystrophies are a group of rare eye diseases that can cause visual impairment and affect social well-being, independence, and active participation in society.
Carolin Elhardt, Ahmad Zia Aamoon, Lennart Maximilian Hartmann, Clara Marie Sophie Grün, Armin Wolf, Christian Maximilian Wertheimer   +5 more
doaj   +1 more source

Questions of treatment of degenerative changes in the anterior chamber of the eye

Медицинский совет, 2016
Degenerative corneal diseases represent a relevant issue in the present-day ophthalmology. The key areas in the treatment of degenerative changes in the anterior chamber of the eye are anti-inflammatory, keratoprotective and tear substitute therapies ...
E. V. Yani, K. E. Seliverstova
doaj   +1 more source

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Corneal dystrophies: Differential diagnosis and management [PDF]

, 1986
Corneal dystrophies: Differential diagnosis and ...
Goodman, Dennis W, Kohn, Benjamin J
core  

Corneal transplantation: Restoring sight to the blind

Acta Ophthalmologica, EarlyView.
Abstract Corneal blindness is one of the leading causes of vision loss worldwide. Transplantation of the cornea can restore vision and make blind patients see again. Corneal transplant surgery has undergone major evolution in recent decades with the advent of minimally invasive lamellar surgical approaches such as DMEK and DALK.
Claus Cursiefen
wiley   +1 more source