Results 141 to 150 of about 161,416 (241)

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

Metabolic and redox adaptations of the corneal endothelium: From metabolic plasticity to therapeutic opportunities. [PDF]

Redox Biol
Jiang D, Hui Neo DJ, Swee-Lim Peh G, Jin P, Chen W, Mehta JS.   +5 more
europepmc   +1 more source

The Innovative Biomaterials and Technologies for Developing Corneal Endothelium Tissue Engineering Scaffolds: A Review and Prospect. [PDF]

Bioengineering (Basel), 2023
Chi M, Yuan B, Xie Z, Hong J.
europepmc   +1 more source

Bioengineered human corneal endothelium for transplantation

, 2008
[[abstract]]Objective: To investigate whether the bioengineered human corneal endothelial cell (HCEC) monolayers harvested from thermoresponsive culture supports could be used as biological tissue equivalents.
Lai, JY; Chen, KH; Hsu, WM; Hsiue, GH; Lee, YH
core  

Clinical and Histopathological Evaluation of Maximal and Supramaximal Energy Direct Selective Laser Trabeculoplasty (DSLT): A Rabbit Model Safety Study

Lasers in Surgery and Medicine, Volume 58, Issue 8, Page 693-703, October 2026.
ABSTRACT Objectives This study aimed to assess the clinical and histopathological effects of maximal available and supramaximal energy exposure in direct selective laser trabeculoplasty (DSLT®) on target and nontarget ocular tissues compared with selective laser trabeculoplasty (SLT) and sham treatments.
Liat Mendel Veig, Zachary Sacks, Dorit Raz‐Prag, Abraham Nyska, Guy Kleinmann   +4 more
wiley   +1 more source

Preoperative Use of the Rho Kinase Inhibitor Ripasudil Protects the Corneal Endothelium from Trabeculectomy-Induced Damage. [PDF]

Clin Ophthalmol
Katsura Y, Fujimoto H, Takata M, Yokoyama H, Sekiya T, Gomi F.   +5 more
europepmc   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Ameliorate NaIO3‐Induced Dry AMD by Delivering miR‐486‐3p to Inhibit Lipocalin‐2‐Mediated Ferroptosis

MedComm, Volume 7, Issue 10, October 2026.
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Zheng Li, Tujing Zhao, Lin Ye, Runze Li, Huaping Tian, Ruilin Liao, Lulin Huang   +6 more
wiley   +1 more source

An Ex Vivo Morphometric Study of the Feline Corneal Endothelium (100 Eyes). [PDF]

Vet Ophthalmol
Soueid Y, Cremer N, Aharon N, Fruchter B, Sebbag L.   +4 more
europepmc   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

A mathematical model of corneal endothelium pump function. [PDF]

J R Soc Interface
Vanone F, Foss AJE, Viola F, Repetto R, Dvoriashyna M.   +4 more
europepmc   +1 more source