Results 1 to 10 of about 44,117 (256)

Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients [PDF]

PLoS ONE, 2017
Oxidative stress is one of the key factors that contributes to the pathogenesis of keratoconus (KC). Macroautophagy is a vital cellular mechanism that is activated in response to oxidative stress.
Rohit Shetty, Kamesh Dhamodaran, Chaitra Jayadev   +2 more
exaly   +2 more sources

Netrin‐4 Modulates Corneal Wound Healing by Enhancing Corneal Epithelium and Nerve Regeneration [PDF]

FASEB BioAdvances
Axon guidance proteins have been found to play a regenerative role in the peripheral nervous system and the cornea. Netrin‐4 is a member of the Netrins family of axon guidance proteins implicated in diabetic retinopathy and corneal hemangiogenesis ...
Cissy Xiao, Daniel Lara‐Newman, Qiang Zhou, Mark I. Rosenblatt, Victor H. Guaiquil   +4 more
doaj   +2 more sources

A novel tissue-engineered corneal epithelium based on ultra-thin amniotic membrane and mesenchymal stem cells [PDF]

Scientific Reports
Currently, in vitro cultured corneal epithelial transplantation is effective in treating limbal stem cell dysfunction (LSCD). Selecting carriers is crucial for constructing the corneal epithelium through tissue engineering. In this study, the traditional
Qiurong Long, Chao Huang, Liying Zhang, Hao Jiang, Su Zhao, Lingli Zhang, Xueer Zheng, Shangkun Ou, Hao Gu   +8 more
doaj   +2 more sources

The Efficacy of Topical Cefiderocol Treatment of Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis Is Dependent upon the State of the Corneal Epithelium [PDF]

Antibiotics
Background: An overlooked factor in the efficacy of topical antibiotics to treat bacterial keratitis is the state of the corneal epithelium. Recently, we evaluated topical cefiderocol for the treatment of extensively drug-resistant (XDR) Pseudomonas ...
Eric G. Romanowski, Jonathan B. Mandell, Vishal Jhanji, Robert M.Q. Shanks   +3 more
doaj   +2 more sources

Comparison of Corneal Stromal Demarcation Line Depth in Epi-off and Epi-on Corneal CrossLinking Using Anterior Segment Optical Coherence Tomograph

Pakistan Armed Forces Medical Journal, 2022
Objective: To compare the corneal stromal demarcation line depth after Epithelium-On and Epithelium-Off corneal crosslinking in patients with keratoconus using anterior segment Optical Coherence Tomography (AS-OCT).
Qurat ul Ain, Omar Zafar, Imran Basit, Manzoor Awan   +3 more
doaj   +1 more source

A native-like corneal construct using donor corneal stroma for tissue engineering. [PDF]

PLoS ONE, 2012
Tissue engineering holds great promise for corneal transplantation to treat blinding diseases. This study was to explore the use of natural corneal stroma as an optimal substrate to construct a native like corneal equivalent. Human corneal epithelium was
Jing Lin, Kyung-Chul Yoon, Lili Zhang, Zhitao Su, Rong Lu, Ping Ma, Cintia S De Paiva, Stephen C Pflugfelder, De-Quan Li   +8 more
doaj   +1 more source

Key Role of Staphylococcal Fibronectin-Binding Proteins During the Initial Stage of Staphylococcus aureus Keratitis in Humans

Frontiers in Cellular and Infection Microbiology, 2021
ObjectivesStaphylococcus aureus is one of the main causes of bacterial keratitis in humans. This study was aimed at investigating the mechanisms of S.
Corantin Maurin, Emilie Courrier, Zhiguo He, Josselin Rigaill, Josselin Rigaill, Jérôme Josse, Frédéric Laurent, Frédéric Laurent, Frédéric Laurent, Philippe Gain, Philippe Gain, Gilles Thuret, Gilles Thuret, Paul O. Verhoeven, Paul O. Verhoeven   +14 more
doaj   +1 more source

Correlation between corneal demarcation line depth in epithelium-off and trans-epithelium accelerated corneal cross linking and keratoconus progression [PDF]

International Journal of Ophthalmology, 2020
AIM: To compare corneal demarcation line (DL) depth in both accelerated epithelium-off and trans-epithelium cross linking (CXL) using anterior segment optical coherence tomography (AS-OCT) and its relation to maximum keratometry (Kmax) progression in ...
Mahmoud Abdel-Radi, Zeiad Eldaly, Hazem Abdelmotaal, Reham Abdelrahman, Mohamed Sayed, Kamel Soliman   +5 more
doaj   +1 more source

Impact of Different Oxygen Supply Methods on the Healing of Corneal Epithelial Wound and the Level of Acetylcholine

Journal of Ophthalmology, 2021
Purpose. To investigate the impact of different oxygen supply methods on corneal epithelial wound healing and acetylcholine level during wound healing. Methods. We randomly divided 75 rabbits into three groups: A, B, and C, with 25 rabbits in each group.
Shanshan Li, Gang Ding, Yuqin Sun, Chenming Zhang   +3 more
doaj   +1 more source

Limbal Stem Cell Deficiency: A Review Focusing on Staging, Diagnostic and Treatment Modalities [PDF]

Journal of Clinical and Diagnostic Research, 2023
The cornea being a transparent tissue acts as a refractive surface as well as a protective barrier of the eye. The corneal epithelium is being continuously replaced and renewed by the Limbal Stem Cells (LSC).
Archana Ramkrishna Thool, Vaibhavi Wasnik   +1 more
doaj   +1 more source