Results 61 to 70 of about 802,092 (249)

Surgery versus epilation for the treatment of minor trichiasis in Ethiopia: a randomised controlled noninferiority trial. [PDF]

, 2011
Trachomatous trichiasis can cause corneal damage and visual impairment. WHO recommends surgery for all cases. However, in many regions surgical provision is inadequate and patients frequently decline.
Saul N. Rajak, Habtamu, E, Amir Bedri Kello, Helen A Weiss, Emerson Paul M., Peng T. Khaw, Weiss Helen A., Rajak, SN, Gebre Teshome, Burton Matthew J., Helen A. Weiss, Gebre, Teshome, Robin L Bailey, Paul M Emerson, Matthew J. Burton, Gilbert, CE, Clare E Gilbert, Matthew J Burton, Khaw Peng T., Rajak Saul N., Habtamu Esmael, Saul N Rajak, David C. W. Mabey, Emerson, PM, Weiss, Helen A, Kello, AB, Genet, A, Khaw, PT, Genet Asrat, Bailey Robin L., Gebre, T, Bailey, RL, Gilbert Clare E., David C W Mabey, Clare E. Gilbert, Rajak, Saul N, Habtamu, Esmael, Kello Amir Bedri, Teshome Gebre, Weiss, HA, Peng T Khaw, Burton, Matthew J, Esmael Habtamu, Mabey David C. W., Genet, Asrat, Kello, Amir Bedri, Gilbert, Clare E, Emerson, Paul M, Bailey, Robin L, Khaw, Peng T, Asrat Genet, Mabey, DC, Paul M. Emerson, Mabey, David CW, Burton, MJ, Robin L. Bailey   +55 more
core   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Corneal model of initial inflammation, wound recovery, and recurrent inflammation.

, 2014
A. Schematic depicts timing of corneal suture placement and removal to induce four distinct tissue microenvironmental conditions: healthy unmanipulated, initial inflammation, wound recovery, and recurrent inflammation. B.
Alicia L. Connor (657169), Michael A. Hollingsworth (179339), Philip M. Kelley (657170), Richard M. Tempero (657171), Darci M. Fink (657168), Maria M. Steele (477095)   +5 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Polysaccharide hydrogel combined with mesenchymal stem cells promotes the healing of corneal alkali burn in rats. [PDF]

PLoS ONE, 2015
Corneal chemical burns are common ophthalmic injuries that may result in permanent visual impairment. Although significant advances have been achieved on the treatment of such cases, the structural and functional restoration of a chemical burn-injured ...
Yifeng Ke, Yixiang Wu, Xuan Cui, Xun Liu, Min Yu, Chunbo Yang, Xiaorong Li   +6 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Acute corneal edema without epithelium compromise. A case report and literature review

Revista de la Facultad de Medicina, 2017
Acute corneal edema is caused by various factors, with different levels of severity, and various forms of presentation. This paper reports the case of a male patient presenting with acute corneal edema without epithelium compromise, whose clinical ...
José Augusto Urrego-Díaz, Juan Sebastián Frías-Ordoñez, Germán Figueroa-Echandía, Guillermo Durán-Silva   +3 more
doaj   +1 more source