Results 81 to 90 of about 802,092 (249)

Особливості реорганізації структур рогівки кролів з її хімічним опіком на тлі мерказоліл-індукованого гіпотирозу = Peculiarities of reorganization of the rabbits’ corneal structure with its chemical burn at the background of merkazolil-induced hypothyroidism [PDF]

, 2014
Savchuk Z. L., Klishch I. M., Herasymiuk I. Ye. Особливості реорганізації структур рогівки кролів з її хімічним опіком на тлі мерказоліл-індукованого гіпотирозу = Peculiarities of reorganization of the rabbits’ corneal structure with its chemical burn at
Savchuk, Z. L., Herasymiuk, I. Ye., Klishch, I. M.   +2 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Birefringent properties of the human cornea in vivo : towards a new model of corneal structure [PDF]

The fundamental corneal properties of mechanical rigidity, maintenance of curvature and optical transparency result from the specific organisation of collagen fibrils in the corneal stroma. The exact arrangement of stromal collagen is currently unknown
Misson, Gary P.
core  

Umbilical Cord Stem Cells in the Treatment of Corneal Diseases

, 2023
To restore transparency and function, corneal specialists currently utilise stem cells of different origins, bioengineered cells and biomaterials. Stem cells are capable of giving rise to progenies with specific functional and morphological traits and in
McGhee, Charles NJ, Ziaei, Mohammed, Patel, Dipika V, Zhang, Jie   +3 more
core   +1 more source

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

A novel therapy to ameliorate nitrogen mustard-induced limbal stem cell deficiency using lipoprotein-like nanoparticles

npj Regenerative Medicine
Chronic corneal inflammation, a component of sulfur mustard (SM) and nitrogen mustard (NM) injuries frequently leads to limbal stem cell deficiency (LSCD), which can compromise vision.
Elif Kayaalp Nalbant, Timothy J. Feliciano, Aliakbar Mohammadlou, Vincent L. Xiong, Jacquelyn E. Trujillo, Andrea E. Calvert, Nihal Kaplan, Parisa Foroozandeh, Jayden Kim, Emma M. Bai, Xiaolin Qi, Fernando Tobias, Eric W. Roth, Vinayak P. Dravid, Kurt Q. Lu, SonBinh T. Nguyen, C. Shad Thaxton, Han Peng, Robert M. Lavker   +18 more
doaj   +1 more source

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Corneal inflammation, especially severe corneal inflammation, plays a significant role in the development of corneal limbal stem cell dysfunction. Constructing appropriate animal models can help us focus on the effects of severe inflammation on corneal ...
Zhang, Liying, Zhang, Lingli, Zheng, Xueer, Wu, Yiming; id_orcid, Gu, Hao, Ou, Shangkun, Zhang, Meng, Tian, Xiaoyu   +7 more
core   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Mesenchymal Stem Cell-Derived Extracellular Vesicles for Corneal Wound Repair

Stem Cells International, 2019
With the immunoregulation potential, mesenchymal stem cells (MSCs) have been used for tissue regeneration by relieving inflammation in the injured tissues.
Hongyan Tao, Xiaoniao Chen, Hongmei Cao, Lingyue Zheng, Qian Li, Kaiyue Zhang, Zhibo Han, Zhong-Chao Han, Zhikun Guo, Zongjin Li, Liqiang Wang   +10 more
doaj   +1 more source