Results 121 to 130 of about 1,194,426 (349)

Phase 2 randomized, double-masked, vehicle-controlled trial of recombinant human nerve growth factor for neurotrophic keratitis [PDF]

, 2018
Purpose: To evaluate the safety and efficacy of topical recombinant human nerve growth factor (rhNGF) for treating moderate-to-severe neurotrophic keratitis (NK), a rare degenerative corneal disease resulting from impaired corneal innervation.
Alio, Jorge, Allegretti, Marcello, Aragona, Pasquale, Benitez del Castillo, José, Bonini, Stefano, Bonini, Stefano, Borderie, Vincent, Carley, Fiona, Chao, Wendy, Creuzot-Garcher, Catherine, Cursiefen, Claus, Dart, John, De La Paz, Maria, Etxebarria, Jaime, Figueiredo, Francisco, Fogagnolo, Paolo, Gabison, Eric, Geerling, Gerd, Hossain, Parwez, Kanna, Ramaesh, Koppen, Carina, Kruse, Friedrich, Lambiase, Alessandro, Lambiase, Alessandro, Leonardi, Andrea, Lorenz, Katrin, Malecaze, François, Mantelli, Flavio, Mastropasqua, Leonardo, Mencucci, Rita, Merayo-Lloves, Jesús, Messmer, Elisabeth, Montero, Jesus, Murta, Joaquim Neto, Nemeth, Janos, Rama, Paolo, Rama, Paolo, Rauz, Saaeha, Reinhard, Thomas, Robert, Pierre-Yves, Rolando, Maurizio, Sainz de la Maza, Maite, Sinigaglia, Francesco, Szaflik, Jacek P., Torrao, Luis, Wylegala, Edward   +45 more
core   +1 more source

A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease

Acta Ophthalmologica, EarlyView.
Abstract Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder that significantly impacts patients' quality of life, with prevalence rates ranging from 5% to 50% and higher incidence in women.
Antonio J. Mateo Orobia, José Manuel Benítez del Castillo, Margarita Calonge, Christophe Baudouin, Marc Labetoulle   +4 more
wiley   +1 more source

Case Report: Simultaneous penetrating keratoplasty with autologous simple limbal epithelial transplantation as an alternative to keratoprosthesis [version 3; peer review: 2 approved]

F1000Research, 2023
Introduction and importance: This case report highlights the multidisciplinary approach required to achieve successful anatomical and functional outcomes, in an eye with total limbal stem cell deficiency (LSCD) associated with underlying corneal scarring
Swati Singh, Swapna S. Shanbhag, Supriya Sharma   +2 more
doaj  

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond [PDF]

, 2014
Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Bultynck, Geert, D'hondt, Catheleyne, Himpens, Bernard, Iyyathurai, Jegan, Leybaert, Luc   +4 more
core   +2 more sources

Progression and topographic subtypes of Terrien marginal degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose To report long‐term outcomes and to search for immunological and genetic risk factors in Terrien marginal degeneration (TMD). Methods Retrospective, in part prospective, hospital‐based longitudinal follow‐up study of 32 eyes of 16 Finnish patients from 2012 to 2023. Median follow‐up was 7.3 years (range, 0.3–15.2).
Minna Ruutila, Pauliina Repo, Annamari T. Immonen, Joni A. Turunen, Marja‐Liisa Lokki, A. Inkeri Lokki, Jukka Moilanen, Kari Krootila, Tero T. Kivelä   +8 more
wiley   +1 more source

Marked mitigation of transplant vascular sclerosis in FasL(gld) (CD95L) mutant recipients. I. The role of alloantibodies in the development of chronic rejection [PDF]

, 1999
Background. In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death.
Aitouche, A, Fung, JJ, Rao, AS, Salam, A, Starzl, TE, Subbotin, V, Sun, H, Valdivia, LA   +7 more
core   +1 more source

Genetic diversity of Acanthamoeba and clinical outcome predictors in Danish patients with Acanthamoeba keratitis

Acta Ophthalmologica, EarlyView.
Abstract Purpose Acanthamoeba keratitis (AK) is a severe corneal infection with potential detrimental effects on visual outcome and quality of life, primarily affecting young contact lens wearers. We report Acanthamoeba genotypes, subtypes and clinical outcome from Danish patients with AK. Methods Thirty‐nine PCR‐positive AK cases diagnosed and treated
Sandra M. Skovdal, Christen Rune Stensvold, Henrik Vedel Nielsen, Stine Elkjær Nielsen, Jesper Hjortdal, Anders Ivarsen   +5 more
wiley   +1 more source

Analysis of the relevant factors for corneal graft rejection in the southern Liaoning region from 2019 to 2023

Frontiers in Medicine
BackgroundThe study aimed to review the etiology of corneal blindness and investigate the relative risk of corneal graft rejection (CGR) in the southern Liaoning region.MethodsThe clinical records of 359 patients (394 eyes) who underwent corneal ...
Chunxiao Yan, Chunxiao Yan, Zhijian Zhang, Zhijian Zhang, Lin Jin, Mengxin Liu, Tianyi Wang, Tianyi Wang, Jinghao Yang, Jinghao Yang, Lijun Zhang, Lijun Zhang, Lijun Zhang   +12 more
doaj   +1 more source

Transplantation of cultured bovine corneal endothelial cells to rabbit cornea: clinical implications for human studies. [PDF]

, 1979
Denis Gospodarowicz, G. Greenburg, Jorge A. Alvarado   +2 more
openalex   +1 more source

Efficacy of Amniotic Membrane Transplantation for the Treatment of Corneal Ulcers.

Cornea, 2019
PURPOSE To evaluate the outcome of amniotic membrane transplantation (AMTX) as a treatment for corneal ulcers. METHODS Patients treated with AMTX for refractory corneal ulcers between 2012 and 2017 were evaluated in a retrospective analysis.
K. Schuerch, Andrea Baeriswyl, B. Frueh, C. Tappeiner   +3 more
semanticscholar   +1 more source