Results 61 to 70 of about 15,349 (266)

Corneal ulceration associated with Nivolumab use

American Journal of Ophthalmology Case Reports, 2019
Purpose: To describe a case of corneal ulceration associated with Nivolumab use. Observations: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies ...
Jack S. Parker, Wyatt Feagin, Christopher Wang, Marius Heersink, John S. Parker   +4 more
doaj  

Clinical Advances and Challenges in Dose Constraints for Organs at Risk in Proton Therapy: A Systematic Review of the Last Decade's Literature

Precision Radiation Oncology, EarlyView.
This systematic review synthesizes decade‐long evidence from peer‐reviewed literature and clinical guidelines, critically evaluating current understanding of OARs tolerance in proton therapy. Abstract Proton beam therapy has demonstrated significant clinical efficacy across multiple malignancies, primarily attributed to its distinct physical dose ...
Jinghao Duan, Cheng Tao, Shizhang Wu, Chengqiang Li, Jinhu Chen, Tianyuan Dai, Yunyi Fan, Tong Bai, Xiangjuan Meng, Tian Kong, Jian Zhu   +10 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Beauty versus the beast: The UK public prefers less‐extreme body shapes in brachycephalic dog breeds

Veterinary Record, EarlyView.
Abstract Background Brachycephalic dog breeds often exhibit a suite of extreme conformations linked with several severe and long‐term disorders. Despite this, ownership levels of brachycephalic breeds remain high internationally, with physical appearance being an important driver in their acquisition.
Elizabeth Youens, Dan G. O'Neill, Zoe Belshaw, Sayaka Mochizuki, Johanna Neufuss, Mickey S. Tivers, Rowena M. A. Packer   +6 more
wiley   +1 more source

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

VIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou, Qiancheng Mao, Junpeng Chi, Jiankun Zhang, Hao Guo, Jitao Wu, Yuanshan Cui   +6 more
wiley   +1 more source

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

VIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen   +10 more
wiley   +1 more source

A Novel Tectonic Keratoplasty with Femtosecond Laser Intrastromal Lenticule for Corneal Ulcer and Perforation

Chinese Medical Journal, 2016
Background: Small incision refractive lenticule extraction (SMILE) is an effective laser procedure that treats myopia. This research was to describe a novel approach to treat corneal ulcer or perforation using the corneal lenticules obtained from SMILE ...
Yang Jiang, Ying Li, Xiao-Wei Liu, Jing Xu   +3 more
doaj   +1 more source

Insights on caesarean section in the southern tamandua (Tamandua tetradactyla)

Veterinary Record Case Reports, EarlyView.
Abstract An adult female southern tamandua (Tamandua tetradactyla) was rescued and taken to a veterinary centre for wildlife care. The patient's evaluation revealed an abnormal neurological status, along with prostration, diarrhoea, dehydration and bilateral corneal ulcers. Insecticide poisoning (carbamate, organophosphate or organochlorine) and canine
Diego Rodrigues Gomes, Gabriel Corrêa de Camargo, Zara Alves Lacerda, Eunice Oba, Fabiana Ferreira de Souza   +4 more
wiley   +1 more source

Granulomatous mural folliculitis and cytotoxic interface dermatitis in a pygmy goat associated with ovine herpesvirus‐2 and systemic lesions of malignant catarrhal fever

Veterinary Record Case Reports, EarlyView.
Abstract A 1‐year‐old pygmy goat presented with progressive alopecia, skin ulceration and lichenification over the neck, face and body. Empirical treatment for parasitic and fungal causes of skin disease did not produce clinical improvement, prompting a full diagnostic investigation.
Peter Richards‐Rios, Dominic Sharkey
wiley   +1 more source

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

BMC Ophthalmology, 2012
Background Corneal ulceration leading to perforation is associated with infectious and non-infectious destructive conditions in the cornea. The fibrinolytic (plasminogen/plasmin) system is considered to contribute to tissue remodeling in the wound ...
Sugioka Koji, Kodama Aya, Yoshida Koji, Okada Kiyotaka, Fukuda Masahiko, Shimomura Yoshikazu   +5 more
doaj   +1 more source