Results 51 to 60 of about 78,444 (298)

A robust nonlinear scale space change detection approach for SAR images [PDF]

open access: yes, 2013
In this paper, we propose a change detection approach based on nonlinear scale space analysis of change images for robust detection of various changes incurred by natural phenomena and/or human activities in Synthetic Aperture Radar (SAR) images using ...
Müjdat Çetin   +9 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Corner detection and classification using anisotropic directional derivative representations

open access: yes, 2013
This paper proposes a corner detector and classifier using anisotropic directional derivative (ANDD) representations. The ANDD representation at a pixel is a function of the oriented angle and characterizes the local directional grayscale variation ...
Shui, PL, Zhang, WC
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Indoor Reconstruction from Floorplan Images with a Deep Learning Approach

open access: yesISPRS International Journal of Geo-Information, 2020
Although interest in indoor space modeling is increasing, the quantity of indoor spatial data available is currently very scarce compared to its demand.
Hanme Jang, Kiyun Yu, JongHyeon Yang
doaj   +1 more source

Determination of Vickers Hardness in D2 Steel and TiNbN Coating Using Convolutional Neural Networks

open access: yesMetals, 2023
The study of material hardness is crucial for determining its quality, potential failures, and appropriate applications, as well as minimizing losses incurred during the production process.
Juan C. Buitrago Diaz   +4 more
doaj   +1 more source

Robust Image Corner Detection Based on Maximum Point-to-Chord Distance

open access: yes, 2018
This paper first analysed the state-of-the-art corner detection algorithms and then proposed a novel corner detection approach based on a maximum point-to-chord distance.
Yarui He   +5 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Helix angle measurement method based on end face and side image processing of helical gear

open access: yesXi'an Gongcheng Daxue xuebao, 2021
The helix angle measurement of helical gear is difficult and the measurement process is complex. In order to improve the measurement accuracy and efficiency, the method of measuring helix angle of helical gear is proposed, by using two cameras to collect
Shuanjun SONG   +4 more
doaj   +1 more source

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