Results 61 to 70 of about 384,568 (276)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A Checkerboard Corner Detection Method for Infrared Thermal Camera Calibration Based on Physics-Informed Neural Network

Photonics
Control point detection is a critical initial step in camera calibration. For checkerboard corner points, detection is based on inferences about local gradients in the image.
Zhen Zuo, Zhuoyuan Wu, Junyu Wei, Peng Wu, Siyang Huang, Zhangjunjie Cheng   +5 more
doaj   +1 more source

FAST Pre-Filtering-Based Real Time Road Sign Detection for Low-Cost Vehicle Localization

Sensors, 2018
In order to overcome the limitations of GNSS/INS and to keep the cost affordable for mass-produced vehicles, a precise localization system fusing the estimated vehicle positions from low-cost GNSS/INS and low-cost perception sensors is being developed ...
Kyoungtaek Choi, Jae Kyu Suhr, Ho Gi Jung   +2 more
doaj   +1 more source

Feature detection using relative distance and multi-scale technique

Alexandria Engineering Journal, 2022
Corner is an import type of feature point of image and has been widely used in image analysis and vision tasks. To enhance the robustness to contour noise and geometrical transformations and meanwhile improve the localization accuracy, we develop a novel
Shizheng Zhang, Baohuan Li, Ming Chen, Yongxuan Sang, Min Huang   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Estimation of crowd density from UAVs images based on corner detection procedures and clustering analysis

Geo-spatial Information Science, 2019
With rapid developments in platforms and sensors technology in terms of digital cameras and video recordings, crowd monitoring has taken a considerable attentions in many disciplines such as psychology, sociology, engineering, and computer vision.
Ali Almagbile
doaj   +1 more source

Reflectance Intensity Assisted Automatic and Accurate Extrinsic Calibration of 3D LiDAR and Panoramic Camera Using a Printed Chessboard

, 2017
This paper presents a novel method for fully automatic and convenient extrinsic calibration of a 3D LiDAR and a panoramic camera with a normally printed chessboard.
Kawaguchi, Nobuo, Sakurada, Ken, Wang, Weimin   +2 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source