Results 161 to 170 of about 6,097,099 (307)

Metformin Attenuates Myocardial Ischemia–Reperfusion Injury in Rats by Modulating JNK Pathway and Inhibiting PANoptosis Mechanisms

Cardiovascular Therapeutics
Biao Hou, Xuejian Hou, Liyue Zhang, Tingting Liu, Yang Li, Ran Dong   +5 more
doaj   +1 more source

Drug-coated balloons in coronary disease: meta-analysis comparing sirolimus- and paclitaxel-coated technologies. [PDF]

BMC Cardiovasc Disord
Ibraheem M, Abouslima A, Ebrahim A, Ahmed S, Elbahnasawy SE, Gamal MH, Ramadan N, Adel M, Elhady MM.   +8 more
europepmc   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Rapid Progression of Coronary Disease in Fabry Disease: Vulnerable Plaque by Intravascular Ultrasound. [PDF]

JACC Case Rep
Li W, Zhao C, Liu M.
europepmc   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Coronary Artery Bypass Grafting vs Percutaneous Coronary Intervention for Stable Multivessel Coronary Disease in the Current Era. [PDF]

Ann Thorac Surg
DeFazio D, Wei L, Chauhan D, Hayanga JW, Mascio C, Daggubati R, Badhwar V, Mehaffey JH.   +7 more
europepmc   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Association Between C-Reactive Protein–Triglyceride Glucose Index and All-Cause and Cardiovascular Mortality Across Cardiovascular–Kidney–Metabolic Syndrome Stages 0–4

International Journal of Endocrinology
Siqi Yi, Weida Qiu, Yanchen Zhu, Shiping Wu, He Zheng, Qiujin Huang, Yingqing Feng, Ying Wu   +7 more
doaj   +1 more source

Blood Biomarkers and the Risk of Coronary Disease in Atrial Fibrillation. [PDF]

J Am Heart Assoc
Cordova Sanchez A, Wilkinson K, Short SAP, Howard VJ, Judd SE, Goyal P, Soliman EZ, Levitan EB, Safford MM, Cushman M.   +9 more
europepmc   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source