Results 151 to 160 of about 80,986 (261)

Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline

Experimental Physiology, EarlyView.
Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley   +1 more source

Acute cardiovascular changes following heat exposure during simulated shipboard firefighting

Experimental Physiology, EarlyView.
Abstract Like structural firefighting, shipboard firefighting requires extreme exertion. However, shipboard firefighting may be a unique cardiovascular stress as most sailors lack extensive firefighting experience and may complete significant work before reaching the fire scene.
Daniel K. Sweet, Elizabeth M. Lavoie, Hayden W. Hess, Stuart Inglis, Brian Monaco, J. Luke Pryor, Steven E. Reis, David Hostler   +7 more
wiley   +1 more source

Adipsin alleviates cold exposure-induced coronary microvascular dysfunction through a Gα13-dependent mechanism

Ecotoxicology and Environmental Safety
Background: Cold exposure is a well-recognized environmental risk factor that contributes to coronary microvascular dysfunction. Adipsin, an adipokine with known cardioprotective properties, has not been fully explored in the context of cold exposure ...
Chuang Sun, Xuebin Zhang, Yu Duan, Mengyuan Jiang, Xiangxu Wang, Wen Ge, Jiye Zhang, Xiao Zhang, Yan Zhang, Xiaohua Zhang, Jie Lin, Xing Qin, Dongdong Sun   +12 more
doaj   +1 more source

Deletion of Cardiac miR-17-92 Cluster Increases Ischemia/ Reperfusion Injury via PTEN Upregulation [PDF]

, 2017
The miR-17- 92 cluster is necessary for cell proliferation and development of the cardiovascular system. Deletion of this cluster leads to death in neonatal mice.
Prakash, Meeta B
core   +1 more source

Adipose tissue‐derived small extracellular vesicles and blood–brain barrier function in adults with overweight and obesity

Experimental Physiology, EarlyView.
Abstract Obesity is associated with adverse changes in brain structure and function, in part, through crosstalk between adipose tissue (AT) and the brain. AT releases small extracellular vesicles (sEV) that can cross the blood–brain barrier (BBB) and modulate multiple pathophysiological pathways, including BBB function; however, this has never been ...
Shalini Mishra, Yixin Su, Sangeeta Singh, Ashish Kumar, Fang‐Chi Hsu, Gagan Deep, Tina E. Brinkley   +6 more
wiley   +1 more source

A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings [PDF]

, 2017
Obstructive disease of the large coronary arteries is the prominent cause for angina pectoris. However, angina may also occur in the absence of significant coronary atherosclerosis or coronary artery spasm, especially in women.
Ambrosio, Giuseppe, Bugiardini, Raffaele, de Wit, Cor, Habazettl, Helmut, Hansen, Peter Riis, Kaski, Juan Carlos, Pries, Axel R., Schächinger, Volker, Tillmanns, Harald, Tritto, Isabella, Vassalli, Giuseppe, Weis, Michael   +11 more
core  

Evidence for early endothelial dysfunction associated with the ALDH2 rs671 gene variant: A preliminary investigation with young East Asians

Experimental Physiology, EarlyView.
Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that plays an important role in aldehyde detoxification. A large percentage (30–50%) of the East Asian population carry a single point mutation in the ALDH2 gene (ALDH2*2 variant) that causes a severe reduction or lack of ALDH2 enzyme activity, and leads to disrupted cellular ...
Beatrice Lioy, Wagner Ribeiro Pereira, Rehan Junejo, Tiago Peçanha, Guilherme Giannini Artioli   +4 more
wiley   +1 more source

The effect of repeated hot water immersion on microvascular function, glycaemic control and inflammation in White European and South Asian males

Experimental Physiology, EarlyView.
Abstract Individuals of South Asian (SA) descent display a higher risk for cardiovascular disease and type 2 diabetes mellitus than their White European (WE) counterparts. Heat therapy, such as hot water immersion (HWI), can improve microvascular function and glycaemic control, although effects across racial groups are unknown.
David Bellini, Alex Lloyd, Christof A. Leicht, Stephen J. Bailey, Lewis J. James, Matthew J. Maley   +5 more
wiley   +1 more source

Postexercise muscle oxygen uptake kinetics in older breast cancer survivors and healthy individuals: Association with myosteatosis

Experimental Physiology, EarlyView.
Abstract Reduced cardiorespiratory fitness is common among breast cancer survivors and, although traditionally attributed to cardiac dysfunction, might also be related to peripheral skeletal muscle abnormalities. We examined peak and submaximal plantar‐flexion exercise and recovery kinetics for lower‐leg oxygen uptake (V̇O2${\dot V_{{{\mathrm{O}}_2}}}$)
Nathan R. Weeldreyer, Thomas J. McMurtry, Stephen J. Foulkes, Amanda Shewman, Edith Pituskin, Rachel J. Skow, Richard B. Thompson, Justin Grenier, Deirdre E. O'Neill, Robert C. Welsh, Mark J. Haykowsky, Corey R. Tomczak   +11 more
wiley   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source