Results 171 to 180 of about 128,004 (314)

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Quantitative Assessment of Coronary Microvascular Function

, 2017
A healthy, functional microcirculation in combination with nonobstructed epicardial coronary arteries is the prerequisite of normal myocardial perfusion.
Attila Feher, Albert J. Sinusas
core   +1 more source

Association of Time in Range and Time in Tight Range With Cardiovascular Risk Factor Exposure in Youth With Type 1 Diabetes: A Cross‐Sectional Analysis on LDL Cholesterol and Blood Pressure Data From the SWEET International Database

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To test the hypothesis that continuous glucose monitoring (CGM) metrics are independently associated with cardiovascular risk factor (CVRF) exposure, particularly low‐density lipoprotein cholesterol (LDL‐C) and blood pressure (BP), in youth with type 1 diabetes (T1D) enrolled in the international SWEET registry. Materials and Methods This
Claudia Piona, Agata Chobot, Jantje Weiskorn, Arun Shankar, Ingrida Stankute, Katrin Nagl, Marie‐Anne Burckhardt, Christina Kanaka‐Gantenbein, Francesco Gasparini, Marina Cavalin, Eva Hauser, Stefanie Lanzinger, Claudio Maffeis, SWEET Study Group   +13 more
wiley   +1 more source

Association of Hypertensive Disorders of Pregnancy with Coronary Microvascular Dysfunction 8 to 10 Years after Delivery [PDF]

BACKGROUND: Hypertensive disorders of pregnancy (HDP) are associated with subsequent adverse cardiac remodeling and cardiovascular disease. The role of myocardial microvascular disease among individuals with HDP and left ventricular (LV) remodeling as a ...
Chen, Xucai, Straub, Adam C., Berlacher, Kathryn L., Gandley, Robin E., Villanueva, Flordeliza S., Parks, W. Tony, De Jong, Nikki; id_orcid, Catov, Janet M., Countouris, Malamo E., Brands, Judith, Zhu, Jianhui   +10 more
core   +1 more source

A Four‐Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin‐Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction and Objective Treatment with sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) reduces the risk of both cardiovascular and renal outcomes in type 2 diabetes (T2D). The specific mechanism by which this happens has not yet been clarified.
Shawn Gugliandolo, Cassandra Morciano, Andrea Guarneri, Gian Pio Sorice, Marta Giaccari, Luigi Cappannoli, Umberto Capece, Amelia Splendore, Adriana Avolio, Lorenzo Diego Greco, Patricia Iozzo, Rossana Moroni, Alfredo Pontecorvi, Maria Lucia Calcagni, Francesco Burzotta, Domenico D'Amario, Filippo Crea, Lucia Leccisotti, Francesca Cinti   +18 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Serum nonmercaptalbumin to total albumin ratio and bilirubin predict ADL decline in older adults with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
In a longitudinal cohort of older adults with type 2 diabetes, incident ADL disability was evaluated. Higher HNA%, lower serum bilirubin, and older age independently predicted the risk of disability. Their combined assessment may offer clinically useful tools for identifying individuals at elevated risk of functional deterioration.
Yukihiro Inoguchi, Toyoshi Inoguchi, Keiko Yasukawa, Saki Fukuhara, Tomoaki Etoh, Mitsunori Masakado, Mayumi Yamato, Fumio Umeda, Yutaka Yatomi, Teruaki Yamauchi, Masatoshi Nomura   +10 more
wiley   +1 more source

Adipsin alleviates cold exposure-induced coronary microvascular dysfunction through a Gα13-dependent mechanism

Ecotoxicology and Environmental Safety
Background: Cold exposure is a well-recognized environmental risk factor that contributes to coronary microvascular dysfunction. Adipsin, an adipokine with known cardioprotective properties, has not been fully explored in the context of cold exposure ...
Chuang Sun, Xuebin Zhang, Yu Duan, Mengyuan Jiang, Xiangxu Wang, Wen Ge, Jiye Zhang, Xiao Zhang, Yan Zhang, Xiaohua Zhang, Jie Lin, Xing Qin, Dongdong Sun   +12 more
doaj   +1 more source

Association between blood pressure levels and mortality in patients with type 2 diabetes: A retrospective cohort analysis

Journal of Diabetes Investigation, EarlyView.
In this retrospective cohort analysis, systolic blood pressure ≥140 mmHg (vs <130) significantly increased all‐cause, cardiovascular, cerebrovascular, and diabetes mortality, whereas diastolic pressure 80–90 mmHg (vs <80) was associated with lower all‐cause and cardiovascular mortality.
Zhen‐Yu Liu, Zhan‐Ze Ma, Si‐Yan Huo, Chang‐Xiang Liao, Yu‐Xiao Xie, Chen Zeng, Fang‐Jun Xu   +6 more
wiley   +1 more source

Relationship Between Hyperinsulinemia and Coronary Microvascular Disease

Qiang Tan,1 Chenhong Zu,2 Wenli Zhang,1 Jia Hao,2 Yang Li,2 Qiang Lu,3 Zhimeng Li,2 Yao Guo2 1Department of Cardiology, Peking University Third Hospital Qinhuangdao Hospital, Qinhuangdao, Hebei, People’s Republic of China; 2Department of Cardiology, the ...
Zhang W, Li Y, Li Z, Zu C, Hao J, Guo Y, Lu Q, Tan Q   +7 more
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