Results 181 to 190 of about 128,004 (314)

Causal effects of lifestyle and socioeconomic factors on diabetes and its complications and comorbidities: A Mendelian randomization study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims Diabetes poses a growing global health burden. This study investigated the causal effects of lifestyle and socioeconomic factors on diabetes risk and related complications and comorbidities. Materials and Methods We applied two‐sample univariable and multivariable Mendelian randomization to assess the causal impact of 26 lifestyle and ...
Qian Yu, Zhaowei Kong, Qingde Shi, Chak Kwong Cheng, Jia Zhang, Jinlei Nie   +5 more
wiley   +1 more source

Testing for Coronary Microvascular Dysfunction [PDF]

JAMA, 2019
openaire   +2 more sources

Dapagliflozin does not impair microvascular hemorheology in type 2 diabetes mellitus: A multicenter randomized controlled trial (D‐PATH study)

Journal of Diabetes Investigation, EarlyView.
Graphical abstract illustrating the study design, physiological rationale, and key findings of the D‐PATH trial. Dapagliflozin, an SGLT2 inhibitor, lowers HbA1c and body weight while increasing hematocrit and erythropoietin levels. Although an elevated hematocrit could theoretically increase blood viscosity and impair microcirculatory flow, ex vivo ...
Yuki Nakatani, Nobuyuki Banba, Shoya Ono, Tomoki Turumi, Megumi Hoshiai, Takushi Sugiyama, Takashi Tomoe, Hajime Tamiya, Naoyuki Otani, Hiroyuki Sugimura, Hidekazu Ikemiyagi, Yusuke Ohya, Koji Yokokawa, Shinichiro Ueda, Yoshimasa Aso, Yasuhiro Maejima, Takanori Yasu   +16 more
wiley   +1 more source

Sudomotor dysfunction in people with type 1 diabetes with and without clinical peripheral neuropathy: A study from Pune, India

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background and Aims It is appreciated that current screening tools for diabetic peripheral neuropathy (DPN) often fail to detect early disease. Sudomotor (sweat gland) dysfunction, among the earliest manifestations of DPN, can be measured objectively by the SUDOSCAN® device. We compared SUDOSCAN® with conventional validated screening (Michigan
Rohan Shah, Rishikesh Behere, Aboli Bhalerao, Sanat Phatak, Alma Baptist, Chinmay S. Marathe, Chittaranjan S. Yajnik   +6 more
wiley   +1 more source

Brain pathology in relation to somatic diseases: Exploring the body–brain crosstalk

Journal of Internal Medicine, EarlyView.
Abstract Several somatic diseases have been consistently linked with an increased dementia risk. However, the underlying neuropathological substrates remain poorly characterized. This narrative review aims to summarize evidence on the association between common age‐related somatic conditions (i.e., heart diseases, type 2 diabetes, kidney disease, liver
G. Grande, M. Valletta, F. Gasparini, D. L. Vetrano, M. Canevelli, J. R. Bacci, C. Qiu, A. Marengoni, M. Toccaceli Blasi, H. Xu, L. Fratiglioni, M. M. Mielke   +11 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Myocardial Parameters for Detecting Coronary Microvascular Dysfunction

Myocardial ischemia, a hallmark of coronary artery disease (CAD), is not always caused by the narrowing or blockage of the epicardial coronary arteries. In many patients, coronary microvascular dysfunction (CMD) plays a pivotal role.
Hui, Chloe Tse Ching, Liu, Haipeng; id_orcid, Sun, Linlin, Wang, Xinhong, Wang, Zhen, Hui, Jeremy Man Ho   +5 more
core   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline

Experimental Physiology, EarlyView.
Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley   +1 more source

Acute cardiovascular changes following heat exposure during simulated shipboard firefighting

Experimental Physiology, EarlyView.
Abstract Like structural firefighting, shipboard firefighting requires extreme exertion. However, shipboard firefighting may be a unique cardiovascular stress as most sailors lack extensive firefighting experience and may complete significant work before reaching the fire scene.
Daniel K. Sweet, Elizabeth M. Lavoie, Hayden W. Hess, Stuart Inglis, Brian Monaco, J. Luke Pryor, Steven E. Reis, David Hostler   +7 more
wiley   +1 more source