Multicentre retrospective propensity‐score‐matched cohort study (n = 286; 3 centres, Pakistan; 2015‐2023) comparing electrophysiological substrate and 12‐month ablation outcomes in patients with atrial fibrillation and hypertrophic cardiomyopathy (HCM‐AF, red) versus lone atrial fibrillation (Lone AF, green; 1:1 PSM on 14 covariates).
Umair Abrar +7 more
wiley +1 more source
Relationship Between Epicardial Fat Volume and Coronary Microvascular Dysfunction. [PDF]
Ito T +9 more
europepmc +1 more source
Biogenic silver nanoparticles exhibit antidiabetic potential by improving glycemic control, enhancing insulin sensitivity, and preserving pancreatic β‐cell function. They act through antioxidant and anti‐inflammatory mechanisms, modulating ROS, NF‐κB, and PI3K/Akt pathways, while providing multi‐organ protection, highlighting their promise as ...
Nourhane A. Darwich +2 more
wiley +1 more source
Impact of Coronary Microvascular Dysfunction on Left Ventricular Function After Percutaneous Coronary Intervention: Assessment With Combined Dipyridamole-Exercise Stress and Myocardial Strain/Work. [PDF]
Zhao W +12 more
europepmc +1 more source
Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets
Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang +7 more
wiley +1 more source
Differential Interaction of High Microvascular Resistance With Coronary Flow Reserve Across Coronary Microvascular Dysfunction Endotypes. [PDF]
Tas A +11 more
europepmc +1 more source
The current study used two large‐scale cohorts to investigate the association between FIB‐4 index and all‐cause and cardiac‐mortality risk. Elevated FIB‐4, both as categorical and continuous variable, was associated with increased risk of all‐cause and cardiac‐mortality. ABSTRACT Determining the link between fibrosis‐4 index (FIB‐4) score, which serves
Chenxi Song +11 more
wiley +1 more source
Monocyte IL-1β predicts adverse cardiovascular events and associates with coronary microvascular dysfunction in kidney transplant recipients. [PDF]
Yin Z +9 more
europepmc +1 more source
Inflammation, Immunity, and Cardiovascular Diseases
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo +8 more
wiley +1 more source
Circulating exosomal miR-550a-5p/miR-665 identify coronary microvascular dysfunction and drive endothelial-myocyte crosstalk in type 2 diabetes. [PDF]
Ding X +7 more
europepmc +1 more source

