Results 231 to 240 of about 128,004 (314)

Association of the TyG Index, Cardiometabolic Index, and Epicardial Adipose Tissue With Coronary Artery Disease

Clinical Cardiology, Volume 49, Issue 6, June 2026.
This study demonstrates that the TyG index, CMI, and EATi are independently associated with CAD. CMI partially mediates the relationship between TyG and CAD, whereas EATi contributes through an independent pathway. These findings suggest that integrating metabolic and adiposity‐related markers may improve cardiovascular risk assessment.
Jia Min, Zhai Shumei, Zuo Yuqiang, Yin Yuling, Yang Xu, Xu Lei, Gao Zhihong   +6 more
wiley   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Leptin in Obesity‐Related Heart Failure: Pathophysiological Mechanisms and Therapeutic Implications

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Obesity‐associated adipose tissue dysfunction leads to hyperleptinemia and altered leptin signaling. Through Ob‐Rb/LepR‐mediated pathways, leptin may contribute to neurohormonal activation, endothelial dysfunction, inflammation, oxidative stress, and myocardial remodeling.
Xuemin Li, Weiguo Wang, Yibo Zhang, Pengfei Ding, Xuewen Li   +4 more
wiley   +1 more source

Coronary microvascular dysfunction as an initial clue to the diagnosis of light-chain amyloidosis: a case report. [PDF]

Eur Heart J Case Rep
Bando R, Yagi S, Kadota M, Ise T, Sata M.   +4 more
europepmc   +1 more source

Exposure Pattern Determines Methamphetamine‐Induced Right Ventricular Dysfunction and Vascular Remodeling

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Chronic methamphetamine (MA) exposure caused mild, compensated pulmonary hypertension, whereas binge‐and‐crash exposure produced severe PAH with right‐ventricular dysfunction and marked vascular remodeling. Binge‐crash rats showed elevated plasma HMGB1, while in vitro methamphetamine triggered endothelial HMGB1 release that promoted smooth‐muscle ...
Ashok Kumar, Aatish Mahajan, Balaji Krishnamachary, Ling Chen, Navneet K. Dhillon   +4 more
wiley   +1 more source

Multicenter Prospective Assessment of Coronary Microvascular Dysfunction: Primary Results of the FlowLab Study. [PDF]

JACC Adv
Bergmark BA, Shah S, Toleva O, Maksoud A, Kearney KE, Kobayashi Y, Fahed AC, Hashim H, Sharma A, Blair J, Chehab BM, Kanakadandi U, Jaffer FA, Jeremias A, Gross DA, Baljepally R, Ali ZA, Reddy G, Shlofmitz E, Moussa I, Zhang S, Murphy SA, Ahmed S, Spinelli J, Meinen J, Rapoza RJ, Sabatine MS.   +26 more
europepmc   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

Coronary Microvascular Dysfunction: Bridging the Diagnosis-Treatment Divide in Women with INOCA-A Review. [PDF]

J Clin Med
Agarwal A, Patel R, Khalique OK.
europepmc   +1 more source

Association of Type 2 Diabetes Mellitus With Dietary Vitamin B12 Intake in Individuals With Different Fat Mass and Obesity‐Associated (FTO) Genotypes

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Higher dietary vitamin B12 intake was inversely associated with the odds of type 2 diabetes mellitus among individuals carrying the TT genotype of the FTO rs9939609 polymorphism. These findings highlight the potential role of precision nutrition strategies in diabetes prevention.
Elham Nikoei Foshtomi, Atefeh Tahavorgar, Ali Shamsi‐Goushki, Mahsa Vahdat, Pegah Samani, Maryam Shojaei, Mohammadtaghi Ghorbani Hesari, Ali Moradi, Morteza Abdollahi, Anahita Houshyar Rad, Saeid Doaei, Marjan Ajami, Maryam Gholamalizadeh   +12 more
wiley   +1 more source