Results 221 to 230 of about 128,004 (314)

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Exploring coronary microvascular dysfunction from functional impairment and structural damage. [PDF]

Front Cardiovasc Med
Wen W, Zhang Y, Jia G, Chi Y.
europepmc   +1 more source

Cellular Heterogeneity During Arterial Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu, Paul‐Lennard Mendez, Dimitri Kasakovski, Judith Sluimer   +3 more
wiley   +1 more source

A hemorheological perspective on coronary microvascular dysfunction: Association of erythrocyte parameters with angiography-derived coronary microcirculatory resistance. [PDF]

PLoS One
AlQazzaz A, Lu Y, Bao JY, Mintz GS, Feng J, Zhang Y, Gao S, Song Q, Ning F, Al-Samawi HH, Al-Manj M, Al-Asadi M, Huang X, Guo N.   +13 more
europepmc   +1 more source

Stress native mapping does not distinguish patients with previous myocardial infarction with non‐obstructive coronary arteries from healthy volunteers

Clinical Physiology and Functional Imaging, Volume 46, Issue 4, July 2026.
Abstract Aims Patients with myocardial infarction with non‐obstructive coronary arteries (MINOCA) may be affected by coronary microvascular dysfunction with reduced stress perfusion. Changes in native T1 and T2 reflect changes in myocardial perfusion; therefore, the aim of our study was to investigate whether non‐contrast, adenosine stress native T1 ...
Daniel F. Andersson, Rebecka Steffen Johansson, Per Tornvall, Peder Sörensson, Jannike Nickander   +4 more
wiley   +1 more source

The Relationship Between Sublingual Microcirculatory Structure and Frailty in Renal Transplant Candidates: Exploring Tortuosity & Endothelial Glycocalyx Biomarkers

Microcirculation, Volume 33, Issue 5, July 2026.
ABSTRACT Objective This study investigated the relationship between sublingual microcirculatory tortuosity, frailty index scores, and endothelial glycocalyx blood biomarkers in individuals with chronic kidney disease (CKD). Methods Sublingual microcirculatory videos were analyzed using a 0–4 tortuosity scoring scale. Plasma concentrations of syndecan‐1
Ryan A. P. Homes, Trent Payne, Fiona Giddens, Ross S. Francis, Ruth E. Hubbard, Emily H. Gordon, Mark J. Midwinter   +6 more
wiley   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Association Between the Cholesterol–HDL–Glucose (CHG) Index and 90‐Day Functional Outcomes in Patients with Acute Ischemic Stroke

Brain and Behavior, Volume 16, Issue 6, June 2026.
The CHG index, derived from total cholesterol, high‐density lipoprotein, and fasting blood glucose, was associated with 90‐day functional outcomes after acute ischemic stroke. ABSTRACT Background: Acute ischemic stroke (AIS) is a major cause of global disability and mortality.
Xinyue Yuan, Xiangqi Kong, Mina Zhao, Penghong Li, Haobo Wang, Wei Jing   +5 more
wiley   +1 more source

Clinical and Angiographic Predictors of No‐Reflow and Its Impact on Outcomes in ST‐Elevation Myocardial Infarction: A Retrospective Study

Clinical Cardiology, Volume 49, Issue 6, June 2026.
In 2925 STEMI patients undergoing primary PCI, no‐reflow occurred in 18% and was predicted by age, diabetes, Killip class, thrombus burden, TIMI 0 flow, and delayed presentation. No reflow was associated with higher mortality, complications, and MACE.
Husnain Bashir, F. N. U. Berkha, Jahanzeb Malik, Abida Perveen   +3 more
wiley   +1 more source