Results 41 to 50 of about 1,014,882 (174)

MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes

Cardiovascular Diabetology, 2022
Background Type 2 diabetes (T2D) is associated with coronary microvascular dysfunction, which is thought to contribute to compromised diastolic function, ultimately culminating in heart failure with preserved ejection fraction (HFpEF).
Shawn Veitch, Makon-Sébastien Njock, Mark Chandy, M. Ahsan Siraj, Lijun Chi, HaoQi Mak, Kai Yu, Kumaragurubaran Rathnakumar, Carmina Anjelica Perez-Romero, Zhiqi Chen, Faisal J. Alibhai, Dakota Gustafson, Sneha Raju, Ruilin Wu, Dorrin Zarrin Khat, Yaxu Wang, Amalia Caballero, Patrick Meagher, Edward Lau, Lejla Pepic, Henry S. Cheng, Natalie J. Galant, Kathryn L. Howe, Ren-Ke Li, Kim A. Connelly, Mansoor Husain, Paul Delgado-Olguin, Jason E. Fish   +27 more
doaj   +1 more source

Microvascular Dysfunction in Patients With Type II Diabetes Mellitus: Invasive Assessment of Absolute Coronary Blood Flow and Microvascular Resistance Reserve

Frontiers in Cardiovascular Medicine, 2021
Background: Coronary microvascular dysfunction (CMD) is an early feature of diabetic cardiomyopathy, which usually precedes the onset of diastolic and systolic dysfunction.
Emanuele Gallinoro, Emanuele Gallinoro, Pasquale Paolisso, Pasquale Paolisso, Alessandro Candreva, Konstantinos Bermpeis, Davide Fabbricatore, Davide Fabbricatore, Giuseppe Esposito, Giuseppe Esposito, Dario Bertolone, Dario Bertolone, Estefania Fernandez Peregrina, Daniel Munhoz, Daniel Munhoz, Daniel Munhoz, Niya Mileva, Martin Penicka, Jozef Bartunek, Marc Vanderheyden, Eric Wyffels, Jeroen Sonck, Jeroen Sonck, Carlos Collet, Bernard De Bruyne, Bernard De Bruyne, Emanuele Barbato, Emanuele Barbato   +27 more
doaj   +1 more source

Fluoroscopic methods of assessment of coronary microvascular dysfunction – a review of literature [PDF]

Българска кардиология
A large proportion of patients with angina and evidence of myocardial ischemia do not have obstructive coronary disease. One of the main mechanisms of ischemia/angina with non-obstructive coronary arteries is coronary microvascular dysfunction, which is ...
R. Grigorov, S. Yambolov
doaj   +3 more sources

Adipsin alleviates cardiac microvascular injury in diabetic cardiomyopathy through Csk-dependent signaling mechanism

BMC Medicine, 2023
Background Microvascular complications are associated with an overtly increased risk of adverse outcomes in patients with diabetes including coronary microvascular injury which manifested as disruption of adherens junctions between cardiac microvascular ...
Xuebin Zhang, Yu Duan, Xiao Zhang, Mengyuan Jiang, Wanrong Man, Yan Zhang, Dexi Wu, Jiye Zhang, Xinglong Song, Congye Li, Jie Lin, Dongdong Sun   +11 more
doaj   +1 more source

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury [PDF]

, 1997
Objective: Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the ...
Weber, Christian, Messmer, Konrad, Habazettl, Helmut, Kupatt, Christian, Gerlach, Eckehart, Zahler, Stefan, Becker, Bernhard F., C Kupatt   +7 more
core   +1 more source

Pathophysiology and Diagnosis of Coronary Functional Abnormalities

European Cardiology Review, 2021
Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant coronary atherosclerotic stenosis. This clinical condition has recently been described as ischaemia with non-obstructive coronary arteries (INOCA)
Jun Takahashi, Akira Suda, Kensuke Nishimiya, Shigeo Godo, Satoshi Yasuda, Hiroaki Shimokawa   +5 more
doaj   +1 more source

CORONARY MICROVASCULAR DYSFUNCTION IN PATIENTS AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION DUE TO ACUTE CORONARY SYNDROME

Медична наука України
Background. Possible cause of residual myocardial ischemia after urgent PCI during ACS is coronary microvascular dysfunction. Aim: To study the frequency of coronary microvascular dysfunction in patients who underwent urgent PCI due to ACS ...
E.Yu. Marushko, G.B. Mankovsky, Ya.Yu. Dzhun   +2 more
doaj   +1 more source

Coronary microvascular dysfunction is associated with poor glycemic control amongst female diabetics with chest pain and non-obstructive coronary artery disease

Cardiovascular Diabetology, 2019
Background Patients with type 2 diabetes mellitus are at an increased risk of adverse cardiovascular events compared to those without diabetes. The timing, relative to disease onset, and degree of glycemic control that reduces the risk of adverse ...
Jaskanwal D. Sara, Riad Taher, Nikhil Kolluri, Adrian Vella, Lilach O. Lerman, Amir Lerman   +5 more
doaj   +1 more source

Outpatient Management of Patients With Angina With No Obstructive Coronary Arteries: How to Come to a Proper Diagnosis and Therapy

Frontiers in Cardiovascular Medicine, 2021
Two-thirds of women and one-third of men who undergo a clinically indicated coronary angiography for stable angina, have no obstructive coronary artery disease (CAD). Coronary vascular dysfunction is a highly prevalent underlying cause of angina in these
Joan G. Meeder, Mariëlle J. Hartzema-Meijer, Tijn P. J. Jansen, Regina E. Konst, Peter Damman, Suzette E. Elias-Smale   +5 more
doaj   +1 more source

Invasive evaluation of coronary microvascular dysfunction

Journal of Nuclear Cardiology, 2022
Coronary microvascular dysfunction (CMD) is a prevalent cause of ischemic heart disease and is associated with poorer quality of life and worse patient outcomes. Both functional and structural abnormalities of the microcirculation can generate ischemia in the absence of epicardial stenosis or worsen concomitant obstructive coronary artery disease (CAD).
Travieso, Alejandro, Jeronimo Baza, Adrian, Faria, Daniel, Shabbir, Asad, Mejía Rentería, Hernán David, Escaned Barbosa, Javier   +5 more
openaire   +4 more sources