Results 91 to 100 of about 22,382 (221)

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, Volume 292, Issue 11, Page 2865-2881, June 2025.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

Stochastic COVID‐19 epidemic model incorporating asymptomatic and isolated compartments

Mathematical Methods in the Applied Sciences, Volume 48, Issue 7, Page 8400-8422, 15 May 2025.
This study delves into the intricate dynamics of the COVID‐19 epidemic by extending a deterministic compartmental model incorporating asymptomatic, quarantined and isolated compartments, with a stochastic model capturing the natural randomness of the processes.
Tomás Caraballo, Ibrahim Bouzalmat, Adel Settati, Aadil Lahrouz, Abdeladim Nait Brahim, Bilal Harchaoui   +5 more
wiley   +1 more source

Development and evaluation of the kit for detection of SARS-associated coronavirus RNA

Терапевтический архив, 2004
Aim. To develop a diagnostic kit for detection of SARS (severe acute respiratory syndrome)-related coronavirus RNA based on reverse transcription and polymerase chain reaction and to estimate its specificity and sensitivity. Material and methods.
G A Shipulin, S В Yatsyshina, V P Chulanov, M Yu Markelov, O Yu Shipulina, А Т Podkolzin, T S Astakhova, A Shishova, - Wuchun Cao, - Liu Wei, - Fan Baochang   +10 more
doaj  

Performance of Subgenomic RT‐PCR for Predicting SARS‐CoV‐2 Infectivity Compared to Genomic RT‐PCR and Culture Isolation

Journal of Medical Virology, Volume 97, Issue 5, May 2025.
ABSTRACT SARS‐CoV‐2 clinical samples can be detected as positive for a long period of time using real‐time RT‐PCR, even when patients are no longer infectious. Viral culture is the gold standard for assessing a patient's infectivity, but it is a time‐consuming technique and lacks sensitivity. SARS‐CoV‐2 subgenomic RNA (sgRNA) detection has been used as
Célia Sentis, Delphine Parraud, Geneviève Billaud, Martine Valette, Maude Bouscambert‐Duchamp, Bruno Lina, Florence Morfin, Alexandre Gaymard   +7 more
wiley   +1 more source

Assembly of viral genomes from metagenomes

Frontiers in Microbiology, 2014
Viral infections remain a serious global health issue. Metagenomic approaches are increasingly used in the detection of novel viral pathogens but also to generate complete genomes of uncultivated viruses.
Saskia L Smits, Saskia L Smits, Rogier eBodewes, Aritz eRuiz-Gonzalez, Aritz eRuiz-Gonzalez, Aritz eRuiz-Gonzalez, Wolfgang eBaumgärtner, Marion P Koopmans, Marion P Koopmans, Albert D. M. E Osterhaus, Albert D. M. E Osterhaus, Anita C Schürch   +11 more
doaj   +1 more source

Myeloid‐Driven Immune Suppression Subverts Neutralizing Antibodies and T Cell Immunity in Severe COVID‐19

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT The objective of this study was to better understand immune failure mechanisms during severe acute respiratory syndrome coronavirus 2, SARS‐CoV‐2 infection, which are critical for developing targeted vaccines and effective treatments. We collected 34 cases representing different disease severities and performed high‐quality single‐cell TCR/BCR
Cong Lai, Su Lu, Yilin Yang, Xiaoyu You, Feixiang Xu, Xinran Deng, Lulu Lan, Yuesheng Guo, Zhongshu Kuang, Yue Luo, Li Yuan, Lu Meng, Xueling Wu, Zhenju Song, Ning Jiang   +14 more
wiley   +1 more source

A New Bat-HKU2–like Coronavirus in Swine, China, 2017

Emerging Infectious Diseases, 2017
We identified from suckling piglets with diarrhea in China a new bat-HKU2–like porcine coronavirus (porcine enteric alphacoronavirus). The GDS04 strain of this coronavirus shares high aa identities (>90%) with the reported bat-HKU2 strains in ...
Lang Gong, Jie Li, Qingfeng Zhou, Zhichao Xu, Li Chen, Yun Zhang, Chunyi Xue, Zhifen Wen, Yongchang Cao   +8 more
doaj   +1 more source

Whole Genome Sequencing and Genetic Diversity of Respiratory Viruses Detected in Children With Acute Respiratory Infections: A One‐Year Cross‐Sectional Study in Senegal

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT Acute respiratory infections (ARI) are a health priority, especially in countries with limited resources. They are a major cause of morbidity and mortality, especially among children and the elderly. In Senegal, the endemic circulation of respiratory viruses other than influenza has been demonstrated.
Anna Julienne Selbé Ndiaye, Sebastien Cortaderona, Léa Delorme, Mamadou Beye, Idir Kacel, Vincent Bossi, Gora Lo, Nafissatou Leye, Abdou Padane, Halimatou Diop‐Ndiaye, Coumba Touré Kane, Ndèye Ramatoulaye Diagne, Cheikh Sokhna, Souleymane Mboup, Pierre‐Edouard Fournier   +14 more
wiley   +1 more source

Coronaviridae

, 2011
Coronavirus and coronavirus-like infections are described in swine, cattle, horses, cats, dogs, rats, birds, bats, rabbits, ferrets, mink, and various wildlife species, although many coronavirus infections are subclinical or asymptomatic. In humans, coronaviruses are included in the spectrum of viruses that cause the common cold and, recently, severe ...
openaire   +1 more source

Opinion and report of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the assessment of the impact of fox population dynamics on public health

Food Risk Assess Europe, Volume 3, Issue 2, April 2025.
ABSTRACT The Red Fox (Vulpes vulpes) can be hunted as a game species. It may also be listed as a “species likely to cause damage” (ESOD – the acronym in French), for public health reasons among others. Conversely, benefits linked to the presence of foxes are also put forward, such as the predation of rodents carrying zoonotic agents.
Emmanuelle Gilot‐Fromont, Isabelle Villena, Elsa Bonnaud, Claude Fischer, Etienne Giraud, Annick Linden, François Meurens, Carine Paraud, Francis Raoul, Céline Richomme, Sandrine Ruette, Michel Trommetter, Isabelle Vallée, Gilles Meyer, Xavier Bailly, Catherine Belloc, Stéphane Bertagnoli, Alain Boissy, Séverine Boullier, Henri‐Jean Boulouis, Eric Cardinale, Aurélie Courcoul, Alice De Boyer Des Roches, Barbara Dufour, Veasna Duong, Lionel Grisot, Claire Guinat, Nadia Haddad, Elsa Jourdain, Hervé Juin, Sophie Le Bouquin‐Le Neveu, Caroline Le Maréchal, Sophie Le Poder, Yves Millemann, Pierre Mormède, Carole Peroz, Claire Ponsart, Claude Saegerman, Jean‐François Valarcher, Isabelle Vallée, Agnès Waret‐Szkuta, Natacha Woronoff‐Rehn, Laura Maxim, Louis‐Georges Soler, Bénédicte Apouey, Luc Baumstark, Céline Bonnet, Thierry Brunelle, France Caillavet, Alain Carpentier, Thomas Coutrot, Cécile Detang‐Dessendre, Serge Garcia, Julien Gauthey, Emmanuelle Lavaine, Christine Le Clainche, Marc Leandri, Youenn Loheac, Sélim Louafi, Eric Plottu, Elodie Rouviere, Maïder Saint‐Jean, Denis Salles, Léa Tardieu, Jean‐Christophe Vergnaud, Philippe Fravalo, Frédéric Auvray, Mickaël Boni, Frédéric Borges, Gilles Bornert, Frédéric Carlin, Catherine Chubilleau, Monika Coton, Georges Daube, Noémie Desriac, Florence Dubois‐Brissonnet, Michel Federighi, Michel Gautier, Michèle Gourmelon, Sandrine Guillou, Stéphane Guyot, Didier Hilaire, Nathalie Jourdan‐da Silva, Claire Le Henaff‐Le Marrec, Sandra Martin‐Latil, Jeanne‐Marie Membré, Eric Oswald, Nadia Oulahal, Pascal Piveteau, Sabine Schorr‐Galindo, Régine Talon, Isabelle Villena, Emmanuelle Robardet, Nathalie Arnich, Karine Fiore, Florence Etoré, Véronique Raimond, Catherine Collignon   +97 more
wiley   +1 more source