Results 71 to 80 of about 23,376 (179)

Isolation of Metabolites With Antiviral Activity From the Brown Algae Dictyota fasciola and Dictyota mediterranea

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Twenty‐one compounds, including six dolabellanes diterpenes and one germacrene sesquiterpene that are new natural products, are reported from the brown algae Dictyota fasciola and Dictyota mediterranea collected from the Aegean Sea. Among them, some exhibit considerable antiviral activity against RNA (HCoV‐NL63, ZIKV) and DNA (HSV‐1) viruses.
Aikaterini Koutsaviti, Elsi‐Evangelia Andriotaki, Maria Harizani, Katarzyna Owczarek, Magdalena Pachota, Aleksandra Synowiec, Artur Szczepański, Paweł Botwina, Krzysztof Pyrć, Vassilios Roussis, Efstathia Ioannou   +10 more
wiley   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

A New Bat-HKU2–like Coronavirus in Swine, China, 2017

Emerging Infectious Diseases, 2017
We identified from suckling piglets with diarrhea in China a new bat-HKU2–like porcine coronavirus (porcine enteric alphacoronavirus). The GDS04 strain of this coronavirus shares high aa identities (>90%) with the reported bat-HKU2 strains in ...
Lang Gong, Jie Li, Qingfeng Zhou, Zhichao Xu, Li Chen, Yun Zhang, Chunyi Xue, Zhifen Wen, Yongchang Cao   +8 more
doaj   +1 more source

Biodiversity and epidemic potential of Chiropteran coronaviruses (Nidovirales: Coronaviridae)

Юг России: экология, развитие, 2020
Aim. The aim of this review is a comprehensive analysis of current literature data on coronaviruses identified in bats.Discussion. Coronaviruses (Coronaviridae) constitute the most extensive family of viruses of the order Nidovirales.
A. M. Shestopalov, Yu. V. Kononova, A. A. Gadzhiev, M. A. Gulyaeva, Marandi Mehdi Vasfi, A. Yu. Alekseev, J. M. Jamalutdinov, M. Yu. Shchelkanov   +7 more
doaj   +1 more source

Multi‐Layered Genomic and Clinical Analysis Identifies Novel Variants, Co‐Occurring Single Nucleotide Polymorphism Pairs, and Clinical Determinants of Host‐Pathogen Interaction in COVID‐19 Severity

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Host genetic factors may contribute to COVID‐19 severity. To identify genetic variants influencing COVID‐19 severity progression, whole‐exome sequencing was performed, followed by an exome‐wide association study on 191 hospitalized patients categorized into three severity groups.
Doris Repušić, Marina Korolija, Ana Livun, Tomo Svaguša, Robert Belužić, Vjekoslav Tomaić, Rosa Karlić, Kristian Vlahoviček   +7 more
wiley   +1 more source

Lung Microbiome Diversity, Infection Dynamics, and Microbe‐Mediated Cross‐Protection

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The protective role of the lung microbiome in maintaining respiratory health by promoting immune homeostasis, pathogen exclusion, and barrier integrity. Diverse microbial communities regulate immune maturation, enhance epithelial defenses, and contribute to antiviral responses, collectively preventing pathogen colonization and sustaining a balanced ...
Sana Arooj, Akmal Zubair, Syeda Zaira Batool, Granaz Niaz, Muhammad Ali, Yasir Waheed, Eman Ramadan Elsharkawy, Naila Afghan   +7 more
wiley   +1 more source

Successful in vitro propagation of feline coronavirus from clinically diagnosed feline infectious peritonitis cases using Vero cells: A potential model for future research

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Feline coronavirus (FCoV) causes inapparent to progressive fatal feline infectious peritonitis (FIP) in domestic and wild cats, which affects multiple‐organ systems. Methods We investigated three clinically sick cats using different laboratory and molecular tests to diagnose and confirm FCoV and propagate the virus in Vero cell ...
Eaftekhar Ahmed Rana, Mahfuza Akther, Susan Beetson, Subir Sarker, Gabriele Rossi, Jasim M. Uddin   +5 more
wiley   +1 more source

Genomic Surveillance of SARS‐CoV‐2 in Senegal (2020–2024): Variant Turnover, Omicron Introductions, and Interregional Spread

Influenza and Other Respiratory Viruses, Volume 20, Issue 6, June 2026.
ABSTRACT Background Genomic surveillance is central to tracking SARS‐CoV‐2 evolution, variant replacement, and transmission dynamics. In Senegal, the Institut Pasteur de Dakar generated one of the largest national longitudinal SARS‐CoV‐2 genomic datasets, offering a unique view of viral spread from the first pandemic wave to the post‐Omicron period ...
Ndeye Awa Ndiaye, Safiétou Sankhe, Mamadou Malado Jallow, Mouhamed Kane, Khadidiatou Ndour, Amadou Diallo, Maimouna Mbanne, Ndeye Marième Top, Seynabou Mbaye Ba Souna Diop, Madeleine Dieng, Issa Gnasse, Debora Goudiaby, Cheikh Talla, Mamadou Aliou Barry, Oumar Faye, Ousmane Faye, Cheikh Loucoubar, Amadou Alpha Sall, Gamou Fall, Marie Henriette Dior Ndione, Moussa Moïse Diagne, Ndongo Dia   +21 more
wiley   +1 more source

Ligand‐Based Pharmacophore Modeling and Structure‐Based Virtual Screening for Identifying Potential Therapeutic Agents Targeting the SARS‐CoV‐2 Spike Protein‐ACE2 Receptor Interaction

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A protocol guided by ligand‐based pharmacophore modeling and structure‐based virtual screening enabled the identification of 1H‐pyrazol‐5‐ol derivatives as novel inhibitors of the SARS‐CoV‐2 spike protein. The lead inhibitors, C‐3 and C‐4, could serve as templates for the design of potent antiviral agents targeting viral entry into host cells ...
Timoteo Delgado‐Maldonado, Gilberto Vargas‐Salas, Debasish Bandyopadhyay, Adriana Moreno‐Rodríguez, Eyra Ortiz‐Pérez, Gildardo Rivera   +5 more
wiley   +1 more source

Family Coronaviridae

, 2017
Members of the family Coronaviridae are large, enveloped, single-stranded RNA viruses. They are the largest known RNA viruses, with genomes ranging from 25 to 32 kb and virions of 118–140 nm in diameter. The family is divided into two subfamilies, the Coronavirinae and the Torovirinae.
openaire   +1 more source