Results 91 to 100 of about 24,885 (199)

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

open access: yesIsrael Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff   +2 more
wiley   +1 more source

A New Bat-HKU2–like Coronavirus in Swine, China, 2017

open access: yesEmerging Infectious Diseases, 2017
We identified from suckling piglets with diarrhea in China a new bat-HKU2–like porcine coronavirus (porcine enteric alphacoronavirus). The GDS04 strain of this coronavirus shares high aa identities (>90%) with the reported bat-HKU2 strains in ...
Lang Gong   +8 more
doaj   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

open access: yesMicrobial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

Biodiversity and epidemic potential of Chiropteran coronaviruses (Nidovirales: Coronaviridae) [Биоразнообразие и эпидемический потенциал коронавирусов (Nidovirales: Coronaviridae) рукокрылых]

open access: yes, 2021
Aim. The aim of this review is a comprehensive analysis of current literature data on coronaviruses identified in bats. Discussion. Coronaviruses (Coronaviridae) constitute the most extensive family of viruses of the order Nidovirales. Coronaviruses have
Shestopalov A.M.
core  

Coronavirus Detection in Bats Captured on the Deforestation Arc of Mato Grosso, Brazil

open access: yesZoonoses and Public Health, Volume 73, Issue 3, Page 281-287, May 2026.
ABSTRACT Coronaviruses (CoV) are RNA viruses associated with enteric and respiratory diseases and known for their emergence potential in humans and other mammals. CoVs originate from zoonotic transmission, in which bats are natural reservoirs. Previous studies suggest that CoV diversity is positively correlated with bat diversity, whereas anthropogenic
Matheus Augusto Calvano Cosentino   +5 more
wiley   +1 more source

Epi-Clock: A sensitive platform to help understand pathogenic disease outbreaks and facilitate the response to future outbreaks of concern

open access: yesHeliyon
To predict potential epidemic outbreaks, we tested our strategy, Epi-Clock, which applies the novel ZHU algorithm to different SARS-CoV-2 datasets before outbreaks to search for significant mutational accumulation patterns correlated with outbreak events.
Cong Ji, Junbin (Jack) Shao
doaj   +1 more source

The PhenX Toolkit: Long COVID Collection of Standard Protocols

open access: yesCurrent Protocols, Volume 6, Issue 4, April 2026.
Abstract Because of the urgent need to better understand the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission mechanism and clinical outcomes resulting from infection, health organizations and research institutes developed data collection instruments to assess coronavirus disease 2019 (COVID‐19) symptoms, treatments, and ...
Michelle C. Krzyzanowski   +10 more
wiley   +1 more source

Improved vaccine strategies of infectious bronchitis disease to reduce shedding of virulent virus from infected birds

open access: yesKufa Journal for Veterinary Medical Sciences, 2017
Infectious bronchitis (IB) threatens the economies of entire nations, by adversely affecting the backyard farmers, poultry producers and poultry industry throughout the world.
Mushtaq T. B. AL-Zuhariy
doaj   +1 more source

Co‐Culture Systems to Study Epithelial‐Immune Interactions During SARS‐CoV‐2 Infection

open access: yesCurrent Protocols, Volume 6, Issue 4, April 2026.
Abstract Robust inflammatory responses to viral infection are mediated by immune cell populations, including monocytes and dendritic cells. However, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) does not replicate efficiently in these cell types and instead preferentially infects epithelial cell subsets in the airway.
Scott H. Randell, Katherine C. Barnett
wiley   +1 more source

Walsh & Hoyt: Coronaviridae

open access: yes, 2005
The Coronaviridae are pleomorphic, enveloped, single-stranded RNA viruses with widely spaced, club-shaped projections (after which they are named). The family is not subdivided into genera but instead into antigenic groups.
Paul W. Brazis, MD, Neil R. Miller, MD
core  

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