Results 91 to 100 of about 24,885 (199)
Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
A New Bat-HKU2–like Coronavirus in Swine, China, 2017
We identified from suckling piglets with diarrhea in China a new bat-HKU2–like porcine coronavirus (porcine enteric alphacoronavirus). The GDS04 strain of this coronavirus shares high aa identities (>90%) with the reported bat-HKU2 strains in ...
Lang Gong +8 more
doaj +1 more source
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley +1 more source
Aim. The aim of this review is a comprehensive analysis of current literature data on coronaviruses identified in bats. Discussion. Coronaviruses (Coronaviridae) constitute the most extensive family of viruses of the order Nidovirales. Coronaviruses have
Shestopalov A.M.
core
Coronavirus Detection in Bats Captured on the Deforestation Arc of Mato Grosso, Brazil
ABSTRACT Coronaviruses (CoV) are RNA viruses associated with enteric and respiratory diseases and known for their emergence potential in humans and other mammals. CoVs originate from zoonotic transmission, in which bats are natural reservoirs. Previous studies suggest that CoV diversity is positively correlated with bat diversity, whereas anthropogenic
Matheus Augusto Calvano Cosentino +5 more
wiley +1 more source
To predict potential epidemic outbreaks, we tested our strategy, Epi-Clock, which applies the novel ZHU algorithm to different SARS-CoV-2 datasets before outbreaks to search for significant mutational accumulation patterns correlated with outbreak events.
Cong Ji, Junbin (Jack) Shao
doaj +1 more source
The PhenX Toolkit: Long COVID Collection of Standard Protocols
Abstract Because of the urgent need to better understand the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission mechanism and clinical outcomes resulting from infection, health organizations and research institutes developed data collection instruments to assess coronavirus disease 2019 (COVID‐19) symptoms, treatments, and ...
Michelle C. Krzyzanowski +10 more
wiley +1 more source
Infectious bronchitis (IB) threatens the economies of entire nations, by adversely affecting the backyard farmers, poultry producers and poultry industry throughout the world.
Mushtaq T. B. AL-Zuhariy
doaj +1 more source
Co‐Culture Systems to Study Epithelial‐Immune Interactions During SARS‐CoV‐2 Infection
Abstract Robust inflammatory responses to viral infection are mediated by immune cell populations, including monocytes and dendritic cells. However, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) does not replicate efficiently in these cell types and instead preferentially infects epithelial cell subsets in the airway.
Scott H. Randell, Katherine C. Barnett
wiley +1 more source
The Coronaviridae are pleomorphic, enveloped, single-stranded RNA viruses with widely spaced, club-shaped projections (after which they are named). The family is not subdivided into genera but instead into antigenic groups.
Paul W. Brazis, MD, Neil R. Miller, MD
core

