Results 21 to 30 of about 870,507 (304)

Vaccine trials during a pandemic: potential approaches to ethical dilemmas

Trials, 2021
Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge.
Manaf Alqahtani, Saad I. Mallah, Nigel Stevenson, Sally Doherty   +3 more
doaj   +1 more source

Coronavirus non-structural protein 1 is a major pathogenicity factor : implications for the rational design of coronavirus vaccines [PDF]

, 2007
Zust, Roland Cervantes-Barragan, Luisa Kuri, Thomas Blakqori, Gjon Weber, Friedemann Ludewig, Burkhard Thiel, Volker 5 R21 AI062246/AI/United States NIAID Research Support, N.I.H., Extramural Research Support, Non-U.S.
Thiel Volker, Friedemann Weber, Cervantes-Barragan, L., Kuri, Thomas, Roland Züst, Kuri Thomas, Weber, Friedemann, Weber, F., Volker Thiel, Luisa Cervantes-Barragán, Kuri, T., Zust, R., Ludewig, Burkhard, Blakqori, Gjon, Gjon Blakqori, Ludewig Burkhard, Burkhard Ludewig, Cervantes-Barragán, Luisa, Weber Friedemann, Thiel, Volker, Thomas Kuri, Ludewig, B., Thiel, V., Züst, Roland, Blakqori Gjon, Züst Roland, Cervantes-Barragán Luisa   +26 more
core   +2 more sources

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Steffen, Imke, Kögl, Manfred, Schwegmann-Wessels, Christel, Pumpor, Ksenia, Müller, Marcel A., Herzog, Petra, Kuri, Thomas, Ditt, Vanessa, Weber, Friedemann, Schwarz, Frank, Pfefferle, Susanne, Schöpf, Julia, Kallies, Stefan, Herrler, Georg, Carbajo-Lozoya, Javier, Zimmer, Ralf, Hilgenfeld, Rolf, Friedel, Caroline C., Dall'Armi, Ekatarina von, Drosten, Christian, Niemeyer, Daniela, Thiel, Volker, Züst, Roland, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Pöhlmann, Stefan, Haas, Juergen G.   +27 more
core   +1 more source

Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH-and Cysteine Protease-Independent Fc gamma R Pathway [PDF]

, 2011
Copyright © 2011, American Society for Microbiology. All Rights Reserved.Public health measures successfully contained outbreaks of the severe acute respiratory syndrome coronavirus (SARS-CoV) infection.
Cheung, Chung y, Marc Daëron, Li, PH, Altmeyer, Ralf, Ping H. Li, Leung, Hiu L, Escriou, N, Dutry, Isabelle, Ming S. Yip, Kien, Francois, Cheung, CY, Dutry, I, Li, Ping H, Benoît Callendret, Nal, B, Chung Y. Cheung, Altmeyer, R, Peiris, J S Malik, Ralf Altmeyer, Bruzzone, R, Jaume, Martial, Martial Jaume, Nicolas Escriou, Callendret, B, Isabelle Dutry, Escriou, Nicolas, Beatrice Nal, Kien, F, Francois Kien, Jaume, M, Yip, MS, Bruzzone, Roberto, J. S. Malik Peiris, Yip, Ming S, Daëron, Marc, Roberto Bruzzone, Hiu L. Leung, Leung, HL, Peiris, JSM, Nal, Beatrice, Daeron, M   +40 more
core   +1 more source

Meeting the Psychological Needs of People Recovering from Severe Coronavirus

, 2020
This guidance considers the likely psychological needs of people who have been hospitalised with severe coronavirus (Covid-19), and the most effective ways to support their ...
Paul, Twose, Wade, Dorothy, Doyle, Ann Marie, Moss-Morris, Rona, Dupont, Simon, Frizelle, Dorothy, Bunnage, Martin, Firschman, Penny, Morrison, Val, Fish, Jessica, Murray, Hannah, Murphy, David   +11 more
core   +7 more sources

Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage [PDF]

, 2012
© 2012 Millet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Béatrice Nal, Millet Jean Kaoru, Malik Peiris, Joseph S., Leung Hiu-Lan, Malik Peiris Joseph S., Siu, YL, Ralf Marius Altmeyer (117263), Siu, Y-L, Nal, B, Chan Wing-Lim, François Kien (117235), Hiu-Lan Leung, Leung, H-L, Yu-Lam Siu (117249), Altmeyer Ralf Marius, Siu Yu-Lam, Jaume, Martial, Martial Jaume, Chan, WL, Kien, F, Jaume, M, Kien François, Jean Kaoru Millet, Béatrice Nal (117269), Millet, Jean, K., Roberto Bruzzone, Millet, JK, Chan, Wing-Lim, Roberto Bruzzone (55052), Li, H, Altmeyer, RM, Millet, Jean Kaoru, Jean Kaoru Millet (117227), Wing-Lim Chan (117252), Bruzzone Roberto, Li Huiying, Hiu-Lan Leung (117257), Kien, François, Cheung, CY, Huiying Li (117255), Yu-Lam Siu, Cheung, Chung-Yan, Cheung Chung-Yan, Millet, Jean, Joseph S. Malik Peiris (117261), Altmeyer, Ralf Marius, Ralf Marius Altmeyer, Chan, W-L, Li, Huiying, Bruzzone, R, Wing-Lim Chan, François Kien, Chung-Yan Cheung, Cheung, C-Y, Bruzzone, Roberto, Leung, Hiu-Lan, Malik Peiris, Joseph S, Nal Béatrice, Siu, Yu-Lam, Jaume Martial, Peiris, JSM, Leung, HL, Nal, Béatrice, Martial Jaume (117259), Huiying Li, Joseph S Malik Peiris, Chung-Yan Cheung (117243)   +66 more
core   +1 more source

COVID-19 Associated Rhino-Orbital Mucormycosis Complicated by Gangrenous and Bone Necrosis—A Case Report from Honduras

Vaccines, 2021
Background: Mucormycosis is a life-threatening invasive fungal infection most commonly observed in immunocompromised patients. Throughout the COVID-19 pandemic, a growing number of Mucorales associated infections, now termed COVID-19 associated ...
Elsa Yolanda Palou, María Auxiliadora Ramos, Emec Cherenfant, Adoni Duarte, Itzel Carolina Fuentes-Barahona, Lysien I. Zambrano, Fausto Muñoz-Lara, Sandra Aracely Montoya-Ramirez, Alex Francisco Cardona-Ortiz, Jorge Alberto Valle-Reconco, Juan J. Montenegro-Idrogo, D. Katterine Bonilla-Aldana, Alberto E. Paniz-Mondolfi, Alfonso J. Rodriguez-Morales   +13 more
doaj   +1 more source

An Engineered HR1-Stem Helix-HR2 Trimeric Platform for Developing Broad-Spectrum Coronavirus Vaccines. [PDF]

Adv Sci (Weinh)
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Sun X, Fan J, Xie X, Shi Y, Liu X, Xu T, Yang S, Shi K, Xie C, Li S, Chen S, Cai R, He P, Ye Y, Chen T, Ma X, Li C, Yu J, Guo D.   +18 more
europepmc   +2 more sources

The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles [PDF]

, 2008
Copyright @ 2008 American Society for Microbiology.The production of virus-like particles (VLPs) constitutes a relevant and safe model to study molecular determinants of virion egress.
Kien, F., Nicholls, JM, Bruzzone, R, Chan, C. M., Tsao, SW, Kien, F, Siu, Y. L., Escriou, N, Altmeyer, R., Nal, B., Nicholls, J. M., Chan, CM, Siu, YL, Lo, J, Peiris, J. S. M., Tsao, S. W., Teoh, KT, Nal, B, Teoh, K. T., Peiris, JSM, Altmeyer, R, Lo, J., Escriou, N., Bruzzone, R.   +23 more
core   +1 more source

Eyes on coronavirus

Stem Cell Research, 2021
Recently, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has spread around the world and is receiving worldwide attention. Approximately 20% of infected patients are suffering from severe disease of multiple systems and in danger of death, while the ocular complications of SARS-CoV-2-infected patients have not been reported generally. Herein,
Li, Yan-Ping, Ma, Ya, Wang, Ningli, Jin, Zi-Bing   +3 more
openaire   +3 more sources