Results 111 to 120 of about 10,287,555 (319)

Longitudinal analysis of SARS-CoV-2 IgG antibody durability in Puerto Rico

Scientific Reports
Understanding the dynamics of antibody responses following vaccination and SARS-CoV-2 infection is important for informing effective vaccination strategies and other public health interventions.
Zachary J. Madewell, Nathan E. Graff, Velma K. Lopez, Dania M. Rodriguez, Joshua M. Wong, Panagiotis Maniatis, Freddy A. Medina, Jorge L. Muñoz, Melissa Briggs-Hagen, Laura E. Adams, Vanessa Rivera-Amill, Gabriela Paz-Bailey, Chelsea G. Major   +12 more
doaj   +1 more source

Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers

Critical Care Explorations, 2020
Objectives:. Coronavirus disease 2019 continues to spread rapidly with high mortality. We performed metabolomics profiling of critically ill coronavirus disease 2019 patients to understand better the underlying pathologic processes and pathways, and to ...
Douglas D. Fraser, MD, PhD, Marat Slessarev, MD, MSc, Claudio M. Martin, MD, MSc, Mark Daley, PhD, Maitray A. Patel, BSc, Michael R. Miller, PhD, Eric K. Patterson, PhD, David B. O’Gorman, PhD, Sean E. Gill, PhD, David S. Wishart, PhD, Rupasri Mandal, PhD, Gediminas Cepinskas, DVM, PhD, On behalf of the Lawson COVID19 Study Team, Robert Arntfield, Ian Ball, Gordon Barkwell, Tracey Bentall, Karen Bosma, Saoirse Cameron, Eileen Campbell, David Carter, Carolina Gillio-Meina, Robert Hegele, Natalya Odoardi, Ram Singh, Kelly Summers, Sue Tereschyn   +26 more
doaj   +1 more source

Modernising epidemic science: enabling patient-centred research during epidemics [PDF]

, 2016
Background: Emerging and epidemic infectious disease outbreaks are a significant public health problem and global health security threat. As an outbreak begins, epidemiological investigations and traditional public health responses are generally mounted ...
Horby, Peter W., Rojek, Amanda M.
core   +3 more sources

Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)

Clinical Infectious Diseases, 2020
Background The emergence of coronavirus disease 2019 (COVID-19) is a major healthcare threat. The current method of detection involves a quantitative polymerase chain reaction (qPCR)–based technique, which identifies the viral nucleic acids when present ...
Li Guo, L. Ren, Siyuan Yang, M. Xiao, De Chang, Fan Yang, C. D. Dela Cruz, Yingying Wang, Chao Wu, Yan Xiao, Lulu Zhang, L. Han, S. Dang, Yan Xu, Qiwen Yang, Sheng-yong Xu, Huadong Zhu, Yingqian Xu, Q. Jin, L. Sharma, Linghang Wang, Jianwei Wang   +21 more
semanticscholar   +1 more source

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

Advanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo   +11 more
wiley   +1 more source

A review of novel coronavirus infection (Coronavirus Disease-19)

Global Journal of Transfusion Medicine, 2020
Coronavirus (CoV) disease-2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome-CoV-2. The disease started in 2019 in Wuhan, China, and has spread globally, resulting in a pandemic. Common symptoms include fever, cough,
Neelesh Jain, Animesh Choudhury, Jayesh Sharma, Venkata Kumar, Divyendu De, Richa Tiwari   +5 more
doaj   +1 more source

Discovering drugs to treat coronavirus disease 2019 (COVID-19).

Drug Discoveries & Therapeutics, 2020
The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. Scientists are endeavoring to find antivirals specific to the virus.
Liying Dong, Shasha Hu, Jianjun Gao
semanticscholar   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New Orleans, August 2020 to September 2021

Scientific Reports
Louisiana experienced high morbidity and mortality from COVID-19. To assess possible explanatory factors, we conducted a cohort study (ClinSeqSer) of patients hospitalized with COVID-19 in New Orleans during August 2020–September 2021.
Arnaud Drouin, Ian D. Plumb, Matthew McCullough, Jade James Gist, Sharon Liu, Marc Theberge, Joshua Katz, Matthew Moreida, Shelby Flaherty, Bhoomija Chatwani, Melissa Briggs Hagen, Claire M. Midgley, Dahlene Fusco   +12 more
doaj   +1 more source

Novel Outcome Biomarkers Identified With Targeted Proteomic Analyses of Plasma From Critically Ill Coronavirus Disease 2019 Patients

Critical Care Explorations, 2020
Objectives:. Coronavirus disease 2019 patients admitted to the ICU have high mortality. The host response to coronavirus disease 2019 has only been partially elucidated, and prognostic biomarkers have not been identified. We performed targeted proteomics
Douglas D. Fraser, MD, PhD, Gediminas Cepinskas, DVM, PhD, Eric K. Patterson, PhD, Marat Slessarev, MD, MSc, Claudio Martin, MD, MSc, Mark Daley, PhD, Maitray A. Patel, BSc, Michael R. Miller, PhD, David B. O’Gorman, PhD, Sean E. Gill, PhD, Guillaume Pare, MD, MSc, Ioannis Prassas, PhD, Eleftherios Diamandis, MD, PhD, on behalf of the Lawson COVID19 Study Team, Robert Arntfield, Ian Ball, Gordon Barkwell, Tracey Bentall, Karen Bosma, Saoirse Cameron, Eileen Campbell, David Carter, Carolina Gillio-Meina, Robert Hegele, Natalya Odoardi, Ram Singh, Kelly Summers, Sue Tereschyn   +27 more
doaj   +1 more source