Results 61 to 70 of about 78,570 (186)
, 2014 Coronaviruses of humans were first identified more than 60 years ago from individuals with respiratory infections, mainly mild. Two different viruses, 229E and OC43 were initially recognized. Because of difficulty in isolating them using standard techniques, many of the early studies of their occurrence were seroepidemiologic. They were confirmed to be
Monto, Arnold S. +2 more
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Coronaviruses in Children, Greece [PDF]
Emerging Infectious Diseases, 2007 To the Editor: Two recently detected human coronaviruses (HCoVs), NL63 and HKU1, increased the number of coronaviruses known to infect humans to 5 (1–3). HCoV-229E and HCoV-NL63 belong to antigenic group 1, HCoV-OC43 and HCoV-HKU1 belong to antigenic group 2, and severe acute respiratory syndrome (SARS)–associated coronavirus (SARS-CoV) is most closely
Anna Papa +7 more
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Advanced Science, EarlyView.Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang +17 more
wiley +1 more source
Evolutionary Relationships between Bat Coronaviruses and Their Hosts
Emerging Infectious Diseases, 2007 Recent studies have suggested that bats are the natural reservoir of a range of coronaviruses (CoVs), and that rhinolophid bats harbor viruses closely related to the severe acute respiratory syndrome (SARS) CoV, which caused an outbreak of respiratory ...
Jie Cui +14 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the danger posed by human coronaviruses.
Mohammed O. Abdelaziz +24 more
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Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, EarlyView.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
Genetic Characterization of Coronaviruses from Domestic Ferrets, Japan
Emerging Infectious Diseases, 2014 We detected ferret coronaviruses in 44 (55.7%) of 79 pet ferrets tested in Japan and classified the viruses into 2 genotypes on the basis of genotype-specific PCR. Our results show that 2 ferret coronaviruses that cause feline infectious peritonitis–like
Yutaka Terada +7 more
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Frontiers in Immunology, 2022 To face the continuous emergence of SARS-CoV-2 variants, broadly protective therapeutic antibodies are highly needed. We here focused on the fusion peptide (FP) region of the viral spike antigen since it is highly conserved among alpha- and ...
Nathalie Vanderheijden +15 more
doaj +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
CLINICAL AND EPIDEMIOLOGICAL PROFILES OF NOVEL VIRUSES IN LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN [PDF]
Romanian Journal of Pediatrics, 2015 Viral respiratory tract infections are one of the leading causes of morbidity and mortality in pediatric pathology. The authors provide the latest information on the structure, pathogenesis, clinical features, epidemiology and response to treatment of ...
Alexandru-Ioan Ulmeanu +2 more
doaj +1 more source