Results 71 to 80 of about 89,490 (232)

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Inactivation of coronaviruses by heat [PDF]

Journal of Hospital Infection, 2020
Indisponível.
Kampf, G., Voss, A., Scheithauer, S.
openaire   +3 more sources

Feline and Canine Coronaviruses: Common Genetic and Pathobiological Features

Advances in Virology, 2011
A new human coronavirus responsible for severe acute respiratory syndrome (SARS) was identified in 2003, which raised concern about coronaviruses as agents of serious infectious disease.
Sophie Le Poder
doaj   +1 more source

Evolutionary Relationships between Bat Coronaviruses and Their Hosts

Emerging Infectious Diseases, 2007
Recent studies have suggested that bats are the natural reservoir of a range of coronaviruses (CoVs), and that rhinolophid bats harbor viruses closely related to the severe acute respiratory syndrome (SARS) CoV, which caused an outbreak of respiratory ...
Jie Cui, Naijian Han, Daniel Streicker, Gang Li, Xianchun Tang, Zhengli Shi, Zhihong Hu, Guoping Zhao, Arnaud Fontanet, Yi Guan, Linfa Wang, Gareth Jones, Hume E. Field, Shuyi Zhang, Peter Daszak   +14 more
doaj   +1 more source

Early protective effect of a (“pan”) coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration

Frontiers in Immunology, 2023
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the danger posed by human coronaviruses.
Mohammed O. Abdelaziz, Mohammed O. Abdelaziz, Martin J. Raftery, Martin J. Raftery, Martin J. Raftery, Julian Weihs, Julian Weihs, Olivia Bielawski, Richard Edel, Julia Köppke, Daria Vladimirova, Julia M. Adler, Theresa Firsching, Anne Voß, Achim D. Gruber, Luca V. Hummel, Ivan Fernandez Munoz, Francesca Müller-Marquardt, Gerald Willimsky, Gerald Willimsky, Gerald Willimsky, Nooran S. Elleboudy, Nooran S. Elleboudy, Jakob Trimpert, Günther Schönrich   +24 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Glycyrrhizin and Coronaviruses [PDF]

, 2020
The SARS-CoV-2 is a novel β-coronavirus, which is enveloped non-segmented positive-sense RNA virus that causes COVID-19 disease. Few studies showed that glycyrrhizin from liquorice root has some anti-viral effect on coronaviruses, what opens the question
Domina Petric
core   +1 more source

Genetic Characterization of Coronaviruses from Domestic Ferrets, Japan

Emerging Infectious Diseases, 2014
We detected ferret coronaviruses in 44 (55.7%) of 79 pet ferrets tested in Japan and classified the viruses into 2 genotypes on the basis of genotype-specific PCR. Our results show that 2 ferret coronaviruses that cause feline infectious peritonitis–like
Yutaka Terada, Shohei Minami, Keita Noguchi, Hassan Y.A.H. Mahmoud, Hiroshi Shimoda, Masami Mochizuki, Yumi Une, Ken Maeda   +7 more
doaj   +1 more source

Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide

Frontiers in Immunology, 2022
To face the continuous emergence of SARS-CoV-2 variants, broadly protective therapeutic antibodies are highly needed. We here focused on the fusion peptide (FP) region of the viral spike antigen since it is highly conserved among alpha- and ...
Nathalie Vanderheijden, Annelies Stevaert, Jiexiong Xie, Xiaolei Ren, Cyril Barbezange, Sam Noppen, Isabelle Desombere, Bruno Verhasselt, Peter Geldhof, Nick Vereecke, Nick Vereecke, Veerle Stroobants, Dayoung Oh, Merijn Vanhee, Lieve M. J. Naesens, Hans J. Nauwynck   +15 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source