Results 91 to 100 of about 92,615 (230)

Coronaviruses

Srpski arhiv za celokupno lekarstvo, 1993
Corona viruses belong to a group of not yet well known viruses isolated in patients with infections of the upper respiratory organs, especially in winter months. It is presumed that they provoke about 15% - 20% of all infections. However, in the last years more attention has been paid to the role of human corona viruses in the provocation of sickness ...
N, Kuljić-Kapulica, A, Budisin
openaire   +3 more sources

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Molecular diversity of coronaviruses in bats [PDF]

, 2006
The existence of coronaviruses in bats is unknown until the recent discovery of bat-SARS-CoV in Chinese horseshoe bats and a novel group 1 coronavirus in other bat species.
Woo, PCY, Li, Kenneth S. M., Poon, Rosana W.S., Yip, Bethanie C.K., Tsoi, Hw, P. Lau, Susanna K., Woo, Patrick C.Y., Poon, Rosana W. S., Wong, BHL, Hoi-wah Tsoi, Kenneth S.M. Li, Kwok-hung Chan, Yuen, Ky, Lau, Susanna K.P., Yip, Bethanie C. K., Wong, Beatrice H. L., Yuen, Kwok-yung, Bethanie C.K. Yip, Lau, Susanna K. P., M. Li, Kenneth S., Yi Huang, Tsoi, Hoi-wah, Kwok-yung Yuen, Woo, Patrick C. Y., Yip, BCK, Huang, Y, Huang, Yi, Chan, Kwok-hung, Beatrice H.L. Wong, Poon, RWS, Li, KSM, Patrick C.Y. Woo, Susanna K.P. Lau, Wong, Beatrice H.L., Rosana W.S. Poon, Lau, SKP, Chan, Kh, Li, Kenneth S.M.   +37 more
core   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Optimization Rules for SARS-CoV-2 M^pro Antivirals: Ensemble Docking and Exploration of the Coronavirus Protease Active Site

Viruses, 2020
Coronaviruses are viral infections that have a significant ability to impact human health. Coronaviruses have produced two pandemics and one epidemic in the last two decades.
Shana V. Stoddard, Serena D. Stoddard, Benjamin K. Oelkers, Kennedi Fitts, Kellen Whalum, Kaylah Whalum, Alexander D. Hemphill, Jithin Manikonda, Linda Michelle Martinez, Elizabeth G. Riley, Caroline M. Roof, Nowreen Sarwar, Doni M. Thomas, Emily Ulmer, Felissa E. Wallace, Pankaj Pandey, Sudeshna Roy   +16 more
doaj   +1 more source

Host Receptors of Influenza Viruses and Coronaviruses—Molecular Mechanisms of Recognition

Vaccines, 2020
Among the four genera of influenza viruses (IVs) and the four genera of coronaviruses (CoVs), zoonotic αIV and βCoV have occasionally caused airborne epidemic outbreaks in humans, who are immunologically naïve, and the outbreaks have resulted in high ...
Nongluk Sriwilaijaroen, Yasuo Suzuki
doaj   +1 more source

Coronaviruses and Multiple Sclerosis [PDF]

, 1994
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system (CNS) without known cause. A popular theory proposes that an exogenous stimulus initiates an immune response against self CNS proteins, possibly myelin structural protein(s).
R S, Murray, G Y, Cai, K, Hoel, S, Johnson, G F, Cabirac   +4 more
openaire   +2 more sources

Porcine circovirus 2 vaccination timing was not associated with piglets’ serological response

Veterinary Record, EarlyView.
Abstract Background The development of immunity in pigs starts in utero, but piglets are born immunologically immature and rely on maternal antibodies. Weaning exposes piglets to multiple stressors, yet vaccination is commonly performed around weaning.
Lea Uotinen, Sanna Nikunen, Gitte Blach Nielsen, Mari Heinonen   +3 more
wiley   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source