Results 91 to 100 of about 89,490 (232)
Coronavirus Replication: Genomes, Subgenomic RNAs, and Defective Viral Genomes [PDF]
With the emergence of the SARS-CoV-2 pandemic the process of coronavirus replication has been under increasing scrutiny. During the replication of their genomic RNA, coronaviruses produce a range of other RNAs in addition to the negative-sense ...
Rory Williams +3 more
core +1 more source
Evolutionary insights into the ecology of coronaviruses [PDF]
, 2007 Although many novel members of the Coronaviridae have recently been recognized in different species, the ecology of coronaviruses has not been established. Our study indicates that bats harbor a much wider diversity of coronaviruses than any other animal
Guan, Y +5 more
core +1 more source
Chemistry – A European Journal, EarlyView.The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma +13 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Serum Apelin‐13 and Galectin‐3 levels were measured by ELISA in COVID‐19–positive patients and controls and evaluated alongside routine biochemical parameters. COVID‐19 patients showed significant alterations in liver, renal, inflammatory, and metabolic markers.
İsmail Uğurlu
wiley +1 more source
Identification of new human coronaviruses [PDF]
, 2007 To date, there are still a variety of human infections with unknown etiology. Identification of previously unrecognized viral agents in patient samples is of great medical interest but remains a major technical challenge.
Pyrc, Krzysztof +2 more
core +1 more source
Balancing risk and reward—Perceptions of bats and their ecological role in Reunion island
People and Nature, EarlyView.Abstract Context: Bats provide vital ecosystem services but can also generate disservices or sanitary concerns, particularly where human–bat interactions are frequent. Understanding public perceptions of bats is essential for effective conservation and risk communication.
Rachel Leong +2 more
wiley +1 more source
The human enteric coronaviruses [PDF]
Postgraduate Medical Journal, 1979 Summary A coronarirus was seen in the faeces from 15 (4·2%) of 355 adults with diarrhoea and from 5 (5·2%) of 96 adults without diarrhoea. Similar particles were seen in the faeces from 5 (2·2%) of 227 children aged 1–14 years with gastroenteritis, but in none of those from 230 infants under one year of age with gastroenteritis.
S K, Clarke, E O, Caul, S I, Egglestone
openaire +2 more sources
Small, EarlyView.During host recognition, the fibers of T7 bacteriophages transition from a capsid bound state to an extended conformation, which requires some level of fiber flexibility. By using high‐speed atomic force microscopy, we show that the fibers have an internal molecular hinge and a torsionally compliant coiled‐coil region.
Luca Elizabet Kosik +16 more
wiley +1 more source
Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery
VIEW, EarlyView.This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf +5 more
wiley +1 more source
VIEW, EarlyView.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley +1 more source