Results 111 to 120 of about 2,432,790 (318)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Revisiting the Relationship of CSR and Corporate Philanthropy by Using Alignment Theory [PDF]

open access: yes, 2015
Both, CSR and corporate philanthropy are expressions of the interferences between the company and its societal environment. However, the question of the relationship between CSR and corporate philanthropy remains unclear.
Stühlinger, Sara, von Schnurbein, Georg
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Corporation and corporate safety

open access: yes, 2019
The subject of the research is theoretical, methodological, scientific and applied provisions for the provision of corporate security of Ukrainian enterprises. The purpose of the research is to provide scientific substantiation of theoretical and methodological provisions and to develop practical recommendations for ensuring corporate security of ...
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Betriebe sind auf alternde Belegschaften kaum eingestellt: Sechs Fragen an Erika Schulz [PDF]

open access: yes
Die Zahl der Personen im Erwerbsalter wird in Deutschland zwar von 2012 an merklich zurückgehen, dieser demographische Effekt wird aber kompensiert durch eine weiter zunehmende Erwerbsbeteiligung.
Corporate author
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

On the validity of corporate green bonds’ environmental claims: is the environmental reporting of corporate green bonds reliable?

open access: yesEnvironmental Research Letters
Green bonds are debt instruments aimed at raising funds for sustainable investments. While issuers must provide post-issuance impact reports to inform investors about the allocation of proceeds, these reports lack standardization and often contain ...
Claudio Petucco   +4 more
doaj   +1 more source

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