Results 131 to 140 of about 671,637 (317)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Frontiers in SustainabilityIntroductionThis study examines Corporate Spiritual Responsibility (CSpR) as an ethical governance framework integrating spirituality into corporate accountability.MethodsA qualitative descriptive–analytical approach was used involving 34 academics ...
Rimi Gusliana Mais +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Corporate Taxation and Corporate Governance [PDF]
The effects of corporate taxation on firm behavior have been extensively discussed in the neoclassical model of firm behavior which abstracts from agency problems.
Marko Köthenbürger +1 more
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An In-Depth Analysis of Barriers to Corporate Sustainability
Administrative SciencesRecent decades have witnessed an unprecedented demand for corporate sustainability. Driven by a desire to remain competitive amidst economic turmoil and climate change, organisations are embedding sustainable measures into their long-term goals and ...
Kennedy Mutua +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Corporate Objective Views and Corporate Governance
, 2007 Presently, corporate governance in various countries is being discussed in many ways. The content of corporate governance itself has some common points, however, due to the difference of their corporate objective views, great differences in the actions ...
後藤, 幸男 +5 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Corporate Collapse and Corporate Governance ::Analysis from Corporate Constitutional Perspective /
This book provides an in-depth examination of the relationship between the UK's dominant corporate governance regime and major corporate failures, with a particular focus on the collapse of Carillion Plc. Through a detailed analysis of the Carillion case
Yang, Yifei.
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