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Pemilihan Platform Tanda Tangan Digital Berdasarkan Faktor Keberlanjutan Selama Pandemi COVID-19 Menggunakan Metode AHP

open access: yesDigital Zone: Jurnal Teknologi Informasi dan Komunikasi, 2021
Sistem tanda tangan digital telah banyak dimanfaatkan terutama untuk kegiatan persetujuan dokumen selama pandemi COVID-19 di Indonesia. Penelitian ini bertujuan untuk mengetahui faktor-faktor dari dimensi sustainability yang mempengaruhi keberlanjutan ...
Ahmad Arif Santosa   +1 more
doaj   +1 more source

Literature review of projects research in the University Institution Pascual Bravo (2009-2012) clúster related to textiles, clothing, fashion design and medellin [PDF]

open access: yesTrilogía Ciencia Tecnología Sociedad, 2013
in this paper, the result of a literature review of the work of grade 2009-2012 period, which lie in the library of the University Institution Pascual Bravo Medellin city, of all technological and vocational programs offering the same
Mario Javier Naranjo Otálvaro
doaj   +1 more source

The Psychos Are Coming, the Psychos Are Coming … They’re Already Here

open access: yesVoices in Bioethics, 2016
American director Steven Soderbergh’s Contagion wastes no time in laying out the context of his film on the contemporary interconnectedness of the earth’s inhabitants and the concomitant susceptibility to catastrophe that such relationships imply ...
Edmund Weisberg
doaj   +1 more source

DESIGN/REDESIGN IN AEROSPACE LOGO GRAPHICS

open access: yesJournal of Industrial Design and Engineering Graphics
: This paper explores the design of logos in the aeronautical field, especially for the Faculty of Aerospace Engineering from Bucharest. The article aims to identify a new image for the Faculty of Aerospace Engineering in order to create a corporate ...
Elena-Raluca RADU
doaj   +6 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

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