Results 51 to 60 of about 822,651 (277)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
DESIGNING THE SYSTEM OF DEVELOPING ENGINEERING PERSONNEL IN ELECTRIC POWER ORGANIZATIONS
Вестник Российского экономического университета имени Г. В. Плеханова, 2017 The article puts forward new approaches to designing the system of shaping and developing engineering personnel in organizations of electric power engineering, which take into account certain specific features of developing labour in today's ...
Elena A. Kosareva
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Automation of Personnel Certification Roadbuilding Departments and Enterprises
International Journal of Advanced Studies, 2015 The article suggests science-based solutions to improve the efficiency of personnel certification of road construction departments and enterprises by developing an integrated learning environment based on an automated system of distance learning with the
Andrey Vladimirovich Ostroukh +2 more
doaj
Computers and Education: Artificial Intelligence, 2021 The applications of artificial intelligence in education have increased in recent years. However, further conceptual and methodological understanding is needed to advance the systematic implementation of these approaches.
Carlos Felipe Rodríguez-Hernández +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
What is the Impact of Blended Learning Including Micro-Learning on Manager Learning and Behavior Change vs. Impact of Classroom Learning? [PDF]
, 2016 Today’s learning trends show that with more information and technology available, a globalized workforce, and a changing way we learn, corporate learning particularly manager training needs to meet the following criteria: Knowledge should be on demand
Avery, Alex
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source