Results 51 to 60 of about 944,761 (290)
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
A Portrait of Raymond Brutinel as a Young Man (Part I): The Future Machine Gun Commander in Edmonton, Alberta, 1905-1914 [PDF]
, 2016 Raymond Brutinel remains one of the Canadian Corps’ most intriguing and little understood senior officers. A fair amount has been written about his service with the Canadian Corps, which generally portrays him as a significant commander and military ...
Pulsifer, Cameron
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
L’appareil numérique et la perspective ou le retour des espaces projectifs en art
Appareil, 2008 Partant de l’idée que la technique n’est affaire ni d’infinité ni de vérité, cet essai interroge les conséquences de la technique et de la technoscience sur l’expérience du corps, de l’espace et du temps.
Michel Porchet
doaj +1 more source
The Corps of Guides, 1903–1914 [PDF]
, 2012 The Canadian Corps of Guides was created in April 1903 by General Order 61, and fell under the purview of the Intelligence Department at Militia Headquarters in Ottawa. However, as the Guides were a service of the Active Militia, and not of the Permanent
Jenkins, Dan
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The power of markets: lessons from Uganda
Forced Migration Review, 2018 Market-based approaches in northern Uganda demonstrate the benefits of supporting local markets instead of distributing in-kind aid.
Alison Hemberger +2 more
doaj
, 2012 Review of Bill Rawling, Surviving Trench Warfare: Technology and the Canadian Corps, 1914-1918.
Hyatt, A.M.J.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source