Results 141 to 150 of about 22,916 (261)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan   +20 more
wiley   +1 more source

EnzRetro: Enzymatic Retrosynthetic Planning With Site‐Specific Reaction Edits Based on Sequence Generative Architecture

open access: yesExploration, EarlyView.
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao   +5 more
wiley   +1 more source

A multi-disciplinary exploration of the press review of the Italian National Institute of Health during the COVID-19 pandemic. [PDF]

open access: yesHum Vaccin Immunother
Fiammenghi C   +8 more
europepmc   +1 more source

Service Work as Lived Experience: A Problematizing Review

open access: yesHuman Resource Management, EarlyView.
ABSTRACT Between employee burnout and growing recruitment challenges, a systemic crisis confronts the service industry. One reason lies in the scope of received human resource management (HRM) approaches, which often emphasize organizational performance metrics at the expense of the emotional, social, and material experiences of doing frontline service
Kushagra Bhatnagar   +2 more
wiley   +1 more source

Recent advances in data‐driven and artificial intelligence‐integrated perovskite solar cells: From design to self‐driving laboratories

open access: yesInfoMat, EarlyView.
To address the limitations of conventional trial‐and‐error approaches, perovskite solar cell research is shifting toward a new paradigm that utilizes datasets and AI. This review examines the fundamental elements of data‐driven and AI‐integrated research: data platforms, AI methodologies, and self‐driving laboratories, demonstrating how their ...
Jaehee Lee   +5 more
wiley   +1 more source

Deep neural architectures for Kashmiri-English machine translation. [PDF]

open access: yesSci Rep
Ul Qumar SM   +5 more
europepmc   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

open access: yesiNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu   +10 more
wiley   +1 more source

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