Results 211 to 220 of about 1,303,482 (284)

Correction equation for QT interval [letter] [PDF]

open access: yesBritish Journal of Clinical Pharmacology, 1985
openaire   +2 more sources

A Novel Nanoantibiotic Formulation With Magnetic and Targeting Potential: Ampicillin‐Conjugated L‐glu–Fe3O4 NPs

open access: yesMicrobiologyOpen, Volume 15, Issue 5, October 2026.
A novel nanoformulation consisting of ampicillin (Amp), l‐glutamic acid (l‐glu), and iron oxide nanoparticles was prepared. l‐glu–Fe3O4–Amp NPs exhibited a controlled drug release profile over a certain period of time. The antibacterial effectiveness of the formulation was proven by agar well diffusion and the LIVE/DEAD BacLight fluorescent assays. The
Mehmet Demirel   +6 more
wiley   +1 more source

Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Peripheral nerve injury triggers axonal degeneration, myelin breakdown, and Schwann cell reprogramming. Remyelination requires reactivation of the SOX10–OCT6–KROX20/EGR2 transcriptional hierarchy, axonal NRG1–ErbB2/3 signaling, metabolic support, and coordinated immune regulation.
Li‐Xin Huang   +13 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Methylphenidate and Long‐Term Risk of Cardiovascular Diseases: A Nationwide Cohort Study

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 10, October 2026.
ABSTRACT Purpose Cardiovascular safety of methylphenidate remains a matter of debate. Methods To evaluate the long‐term cardiovascular risk associated with methylphenidate use, a cohort study was conducted using the French National Health Data System.
Christelle Berthod   +5 more
wiley   +1 more source

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials.
Yao Wang   +9 more
wiley   +1 more source

Application of an Open‐Source Modular Framework for Pharmacokinetic, Pharmacodynamic, and Safety Simulations to Anti‐Tuberculosis Drugs

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Tuberculosis (TB) treatment requires long‐term multidrug regimens where dosing, efficacy, and safety optimization remain challenging. This tutorial establishes an integrated, open‐source, modular framework connecting high‐throughput PBPK (HT‐PBPK) simulations, mechanistic PBPK models, pharmacodynamic endpoints, and safety predictions for anti ...
Marco Siccardi   +9 more
wiley   +1 more source

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