Results 71 to 80 of about 55,874 (301)

Antipsychotic Polypharmacy and Corrected QT Interval: A Systematic Review [PDF]

The Canadian Journal of Psychiatry, 2015
Objective: It remains unclear whether antipsychotic polypharmacy, a common clinical practice, is related to an increased risk of corrected time between start of Q wave and end of T wave (QTc) interval prolongation. We conducted a systematic review of the literature to address this important issue. Method: A systematic literature search was conducted in
Hiroyoshi, Takeuchi, Takefumi, Suzuki, Gary, Remington, Hiroyuki, Uchida   +3 more
openaire   +2 more sources

A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs [PDF]

, 2016
© 2016 Elsevier Ireland Ltd Background The interaction between the PTa and PP interval dynamics from the surface ECG is seldom explained. Mathematical modeling of these intervals is of interest in finding the relationship between the heart rate and ...
Langley, Philip, Palanikumar, Gurusamy, Sivaraman, Jayaraman, Uma, Gandhi, Umapathy, M., Venkatesan, Sangareddi   +5 more
core   +1 more source

Long‐Term Outcomes of Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Patients with Impaired Cardiac Function

Arthritis &Rheumatology, Accepted Article.
Objective High intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced SSc. The role of reduced intensity conditioning (RIC) prior to AHSCT in this population remains unclear. We conducted this study to determine the long‐term outcomes of RIC AHSCT in SSc patients with cardiac ...
Yonatan Lean, Carrie Richardson, Anthony Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population

Heliyon
Objective and rationale: Small studies have shown that the QT interval follows a circadian rhythm. This finding has never been confirmed in a large real-world hospital population and the clinical meaning of disrupted rhythmicity remains unknown. Methods:
Rutger R. van de Leur, Bastiaan C. du Pré, Markella I. Printezi, Rutger J. Hassink, Pieter A. Doevendans, René van Es, Linda W. van Laake   +6 more
doaj   +1 more source

Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose

Substance Abuse Treatment, Prevention, and Policy, 2019
Background Iran is a country with the highest rate of opioid addiction in the world. The most commonly used opioid in Iran is opium, and methadone is in second place. The trend of drug use has changed from opium to methadone from 2006 to 2011.
Davood Soroosh, Mahbubeh Neamatshahi, Bahram Zarmehri, Samaneh Nakhaee, Omid Mehrpour   +4 more
doaj   +1 more source

Use of QT intervals for a more accurate diagnose of syncope and evaluation of syncope severity. [PDF]

, 2014
BACKGROUND: This study aimed to evaluate the use of QT intervals, their diagnostic predictive value in patients with syncope and their relationship with syncope severity.
BUTTA', Carmelo, CANINO, Baldassare, CASUCCIO, Alessandra, DI RAIMONDO, Domenico, GIARRUSSO, Lucia, Licata, G, Lo Vecchio, S, Miceli, G, PINTO, Antonio, TUTTOLOMONDO, Antonino   +9 more
core   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Effects of Neostigmine and Sugammadex for Reversal of Neuromuscular Blockade on QT Dispersion Under Propofol Anesthesia: A Randomized Controlled Trial

Cardiology and Therapy, 2018
Introduction Reversal of non-depolarizing neuromuscular blocking agent neostigmine is associated with QT prolongation under general anesthesia. To clarify the effects of neostigmine and sugammadex on hemodynamic status, the QT interval and QT dispersion ...
Yusuke Yamashita, Toshifumi Takasusuki, Yoshiyuki Kimura, Makoto Komatsuzaki, Shigeki Yamaguchi   +4 more
doaj   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Andersen-Tawil syndrome: report of 3 novel mutations and high risk of symptomatic cardiac involvement. [PDF]

, 2014
IntroductionAndersen-Tawil syndrome (ATS) is a potassium channelopathy affecting cardiac and skeletal muscle. Periodic paralysis is a presenting symptom in some patients, whereas, in others, symptomatic arrhythmias or prolongation of QT in ...
Bieganowska, Katarzyna, Bienias, Piotr, Kaminska, Anna, Kostera-Pruszczyk, Anna, Lee, Hsien-Yang, Miszczak-Knecht, Maria, Ploski, Rafal, Potulska-Chromik, Anna, Pruszczyk, Piotr, Ptáček, Louis J, Quinn, Emily, Szczałuba, Krzysztof   +11 more
core   +2 more sources