Results 121 to 130 of about 4,680,147 (302)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Analytic hierarchy process evaluation model for the introduction of talents among university teachers

open access: yesFrontiers in Education
In this paper, a quantitative evaluation model based on the Analytic Hierarchy Process (AHP) is constructed to addresses the issues of ambiguous evaluation criteria and strong subjectivity in the current talent recruitment process in universities ...
Xu Yanchen
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

Duet procedure to achieve reversible trifocality in a young patient with hereditary hyperferritinemia-cataract syndrome

open access: yesAmerican Journal of Ophthalmology Case Reports, 2021
Ramin Khoramnia   +3 more
doaj   +1 more source

Phone counseling service in a big city

open access: yesКонсультативная психология и психотерапия, 2010
The article presents the reflections of the practice of psychologist who works in phone counseling service: it points out the functions and role of this psychological service for big city life. The author describes social mission and goals of a telephone
Chursina E.A.
doaj  

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