Results 121 to 130 of about 2,274,963 (280)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Comparative visual and refractive analysis of two enhanced monofocal intraocular lenses
BMC OphthalmologyPurpose To compare visual and refractive outcomes and monocular defocus performance between the Isopure 1.2.3 (ISP; PhysIOL, Liège, Belgium) and the TECNIS Eyhance ICB00 (EH; J&J Vision, Santa Ana, CA, USA) intraocular lenses (IOLs).
Hyeck-Soo Son +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Scientific ReportsThis study compared the clinical outcomes and optical characteristics of the TECNIS Eyhance (EH; Johnson & Johnson Vision, Santa Ana, CA, USA) enhanced monofocal and the TECNIS PureSee (PS; Johnson & Johnson Vision) non-diffractive extended-depth-of ...
Hyeck-Soo Son +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Advanced Glycation End Products and Metabolic-Mechanical Coupling in Diabetic Retinopathy
Clinical OphthalmologyLifang Wang,1,2,* Xudong Zhao,2,3,* Yan Wang,2 Wei Chen21Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye
Wang L, Zhao X, Wang Y, Chen W
doaj
Connecticut Department of Correction statistics
, 2010 Began in 2002?; Title from home page last modified 7/3/07 (viewed Dec.
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