Results 121 to 130 of about 6,018,350 (361)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Psychological diagnostics of risky behavior of adolescents

open access: yesПсихіатрія, неврологія та медична психологія, 2020
The article reflects practical results of the research on adolescent risky behavior and specifically – the psychodiagnostics stage. Traditionally therapeutic impact on risky adolescents is not quite effective.
Anastasiia Rakhimkulova
doaj  

Herpes zoster ophthalmicus-induced oculomotor nerve palsy

open access: yesJournal of Optometry, 2013
Herpes zoster ophthalmicus (HZO) may cause a variety of ocular conditions including: dermatitis, corneal pseudo-dendrites, uveitis, retinitis, and cranial nerve palsies.
Jennifer S. Harthan   +1 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Mass SARS-CoV-2 testing in US correctional facilities during the pandemic: a longitudinal analysis

open access: yesBMJ Public Health
Introduction Real-world evidence on the utility of SARS-CoV-2 mass screening in correctional facilities remains limited. The Connecticut Department of Correction (CTDOC) implemented an adaptive testing programme involving serial mass screening with ...
Albert I Ko   +6 more
doaj   +1 more source

NEW PROBIOTIC AGENT FOR THE BOWEL MICROFLORA CORRECTION IN INFANTS

open access: yesВопросы современной педиатрии, 2013
Characteristics of a new probiotic — a biological additive, developed specially for children – and indications for its usage are shown in this article.
E. S. Keshishyan
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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