Results 91 to 100 of about 1,994,246 (328)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Processing Vaccine Misinformation: Recall and Effects of Source Type on Claim Accuracy via Perceived Motivations and Credibility

International Journal of Communication, 2022
This study leverages the persuasion knowledge model (PKM) as a theoretical framework to examine how individuals process attempts at correcting measles, mumps, and rubella vaccine-related misinformation on Facebook. An experiment among U.S.
Michelle A. Amazeen, Arunima Krishna
doaj   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Correction to “Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases” [PDF]

, 2022
Rory Crean, Michal Biler, Marina Corbella, Ana Rita Calixto, Marc W. van der Kamp, Alvan C. Hengge, Shina Caroline Lynn Kamerlin   +6 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

EpICC: A Bayesian neural network model with uncertainty correction for a more accurate classification of cancer [PDF]

, 2022
Prasoon Joshi, Riddhiman Dhar
openalex   +1 more source

Second-Order Leptonic Radiative Corrections for Lepton-Proton Scattering

, 2018
The interpretation of high-precision lepton-nucleon scattering experiments requires the knowledge of higher-order radiative corrections. We present a calculation of the cross section for unpolarized lepton-proton scattering including leptonic radiative ...
Bucoveanu, R. -D., Spiesberger, H.
core   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Correction for Zhu et al., “Bacteria and Metabolic Potential in Karst Caves Revealed by Intensive Bacterial Cultivation and Genome Assembly”

, 2021
Hai-Zhen Zhu, Zhifeng Zhang, Nan Zhou, Cheng‐Ying Jiang, Baojun Wang, Lei Cai, Hongmei Wang, Shuang‐Jiang Liu   +7 more
openalex   +2 more sources