Results 81 to 90 of about 2,002,600 (329)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Value at looking back: Towards an empirical validation of the role of reflexivity in econo-historic backtesting: Economic market prediction corrections correlate with future market performance [PDF]

open access: yesACRN Journal of Finance and Risk Perspectives, 2019
The following article innovatively paints a novel picture of the mass psychological underpinnings of business cycles based on information flows in order to recommend how certain communication strategies could counterweight and alleviate information ...
Julia M. Puaschunder
doaj   +1 more source

Professionalism in the Alaska Department of Corrections: Education and Experience [paper] [PDF]

open access: yes, 1986
A later version of this paper was published as: Schafer, N.E. (1986). "Professionalism in the Alaska Department of Corrections: Education and Experience." The Justice Professional 1(2): 78–95 (Fall 1986).A survey of Alaska corrections personnel reveals ...
Schafer, N. E.
core  

Large-N Baryons, Chiral Loops, and the Emergence of the Constituent Quark

open access: yes, 1995
Meson loop corrections to baryon axial currents are computed in the 1/N expansion. It is already known that the one-loop corrections are suppressed by a factor 1/N; here it is shown that the two-loop corrections are suppressed by (1/N)^2.
Bijnens   +27 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Charged Higgs Boson Production in Bottom-Gluon Fusion

open access: yes, 2002
We compute the complete next-to-leading order SUSY-QCD corrections for the associated production of a charged Higgs boson with a top quark via bottom-gluon fusion. We investigate the applicability of the bottom parton description in detail.
A. Belyaev   +75 more
core   +1 more source

On R**2 Corrections for 5D Black Holes [PDF]

open access: yes, 2007
We study higher order corrections to extremal black holes/black string in five dimensions. These higher order corrections are due to supersymmetric completion of R**2 term in five dimensions.
A. Castro   +30 more
core   +6 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Gluon density in nuclei [PDF]

open access: yes, 1996
In this talk we present our detail study ( theory and numbers) [1] on the shadowing corrections to the gluon structure functions for nuclei. Starting from rather contraversial information on the nucleon structure function which is originated by the ...
Ayala, A. L.   +2 more
core   +2 more sources

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