Results 61 to 70 of about 605,840 (270)

Political Correctness: Implosion of Politics

open access: yesPhilosophies, 2017
The purpose of this article is to develop a critical understanding of political correctness as regressive process of incrimination based on a utopia of non-differentiation.
Alexis Dirakis
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

ON CORRECTNESS OF BAYES FORMULA

open access: yesAdvanced Engineering Research, 2014
The inadmissibility of the comparison and cooperative processing of the conditional probabilities calculated with the use of the known variations of Bayes formula considering a well-defined amount of the accumulated evidences is established.
Alexander Ivanovich Dolgov
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Kino pod presją

open access: yesImages, 2016
Cinema under pressure The article contains a synthetic look at the issue of film censorship, taking into account its various forms. The author combines the perspective of a contemporary synchronous with the diachronic perspective, dating back to the ...
MAREK HENDRYKOWSKI
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Verifying Probabilistic Correctness in Isabelle with pGCL [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2012
This paper presents a formalisation of pGCL in Isabelle/HOL. Using a shallow embedding, we demonstrate close integration with existing automation support.
David Cock
doaj   +1 more source

On equivalences and standardization in a non-deterministic call-by-need lambda calculus [PDF]

open access: yes, 2007
The goal of this report is to prove correctness of a considerable subset of transformations w.r.t. contextual equivalence in a an extended lambda-calculus with case, constructors, seq, let, and choice, with a simple set of reduction rules. Unfortunately,
Mann, Matthias, Schmidt-Schauß, Manfred
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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