Results 51 to 60 of about 3,180,541 (284)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A High-Breakdown MCD-Based Robust Concordance Correlation Coefficient
MathematicsThe concordance correlation coefficient (CCC) is a popular measure of agreement between two continuous variables but is highly sensitive to outliers and data contamination.
Hasan Bulut, Müjgan Zobu, Vedat Sağlam
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2015 In article the mathematico-statistical analysis of quality of dough on the subject "Linear Algebra, Analytical Geometry" is carried out. Quality of dough decides on the help of such characteristics as reliability, a validity and a diskriminativnost.
Larisa V. Limanova +1 more
doaj
Minimum HGR Correlation Principle: From Marginals to Joint Distribution
, 2015 Given low order moment information over the random variables $\mathbf{X} = (X_1,X_2,\ldots,X_p)$ and $Y$, what distribution minimizes the Hirschfeld-Gebelein-R\'{e}nyi (HGR) maximal correlation coefficient between $\mathbf{X}$ and $Y$, while remains ...
Farnia, Farzan +3 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2015 In article the mathematical and statistical analysis of the quality of a test on a subject "Limits. Derivatives" is carried out. The most important characteristics at quality check of a test are reliability and validity.
Larisa V. Limanova, Lidiya A. Muratova
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source