Results 71 to 80 of about 1,187,272 (257)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Character Association and Path Analysis in Indian Garlic (Allium sativum L.) Accessions using Agro-Morphological Traits [PDF]

Madras Agricultural Journal
Character association and path analysis in 25 genotypically diverse indigenous accessions of garlic (Allium sativum L.) were evaluated at Vegetable Farm, CSK HPKV Palampur, for 17 agro-morphological quantitative traits namely, plant height, leaves per
Shivam Sharma, D.R. Chaudhary, Neha Sharma, B.M. Harish   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Multivariate Extension Application for Spearman’s Footrule Correlation Coefficient

Mathematics
This paper presents a simplified and computationally feasible multivariate extension. A correlation matrix is constructed using pairwise Spearman’s footrule correlation coefficients, and these coefficients are shown to jointly converge to a multivariate ...
Liqi Xia, Sami Ullah, Li Guan
doaj   +1 more source

Correlation and path coefficient analysis of economically important traits in Linseed (Linum usitatissimum L.) germplasm

Electronic Journal of Plant Breeding, 2016
Correlation study with 105 linseed germplasms showed that seed yield exhibited highly positive significant correlation with number of primary branches per plant, number of secondary branches per plant, number of capsule per plant, number of seed per ...
R.B.Gudmewad, S.G.Khandagale, Kumara Swamy R.V and, Swati   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Improvement of quality of pedagogical dough from a course of the higher mathematics on a subject "integral calculus"

Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2016
One of ways of control of knowledge is testing of pupils. The purpose of this work is improvement of quality of pedagogical dough on the subject "Integral calculus" of a course of the higher mathematics which is applied to an assessment of knowledge of ...
Larisa V. Limanova
doaj  

Constrained Bayesian Method for Testing Equi-Correlation Coefficient

Axioms
The problem of testing the equi-correlation coefficient of a standard symmetric multivariate normal distribution is considered. Constrained Bayesian and classical Bayes methods, using the maximum likelihood estimation and Stein’s approach, are examined ...
Kartlos Kachiashvili, Ashis SenGupta
doaj   +1 more source