Results 101 to 110 of about 476,574 (303)

A practical evaluation of correlation filter-based object trackers with new features. [PDF]

open access: yesPLoS One, 2022
Mohamed I   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Correlation Filter-Based Visual Tracking for UAV with Online Multi-Feature Learning

open access: yesRemote Sensing, 2019
In this paper, a novel online learning-based tracker is presented for the unmanned aerial vehicle (UAV) in different types of tracking applications, such as pedestrian following, automotive chasing, and building inspection.
Changhong Fu   +3 more
semanticscholar   +1 more source

An Anti-Drift Background-Aware Correlation Filter for Visual Tracking in Complex Scenes

open access: yesIEEE Access, 2019
The model drift problem is an inevitable problem for online visual tracking. Model drift can amplify the false tracking result over time and lead to failed tracking finally.
Shanshan Luo, Baoqing Li, Xiaobing Yuan
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Sampling Operator to Learn the Scalable Correlation Filter for Visual Tracking

open access: yesIEEE Access, 2019
The correlation filter is suitable for tracking on account of its low computational complexity and promising performance. However, the number of available training samples is limited to the filter size, and the lack of samples leads to poor ...
Minkyu Lee   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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