Results 91 to 100 of about 476,574 (303)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Adaptive Weighted CNN Features Integration for Correlation Filter Tracking

open access: yesIEEE Access, 2019
Visual object tracking is an active and challenging research topic in computer vision, as objects often undergo significant appearance changes caused by occlusion, deformation, and background clutter.
Chunbao Li, Bo Yang
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Contribution to the Improvement of the Correlation Filter Method for Modal Analysis with a Spatial Light Modulator. [PDF]

open access: yesMicromachines (Basel), 2022
Benedicto D   +5 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Partial Block Scheme and Adaptive Update Model for Kernelized Correlation Filters-Based Object Tracking

open access: yesApplied Sciences, 2018
In visual object tracking, the dynamic environment is a challenging issue. Partial occlusion and scale variation are typical challenging problems. We present a correlation-based object tracking based on the discriminative model.
Soowoong Jeong, Joonki Paik
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Fast Correlation Tracking Using Low-Dimensional Scale Filter and Local Search Strategy

open access: yesIEEE Access, 2017
Recently, correlation filter-based tracking algorithms have attracted much attention for its high efficiency and robustness. However, achieving fast and accurate scale estimation remains a challenging problem.
Qingyong Hu   +4 more
doaj   +1 more source

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