Results 101 to 110 of about 4,147,721 (229)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Sonic Anti-Correlationism and its Limits: Thinking Quentin Meillassoux with William Basinski
, 2021 The Sound of the Non-Correlational How do we theorize the relationship between the human and the nonhuman? How should this relationship be conceptualized within the field of sound studies? What are the political and conceptual stakes of how we posit the human and the nonhuman?
openaire +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Struggle with Correlationism: Speculative Realism against Heidegger
RUDN Journal of PhilosophyThe main problem that speculative realism, represented by Quentin Meillassoux, Graham Harman and Ray Brassier, is trying to solve is overcoming correlationism. Two important figures who played a key role in the development of correlationism are Immanuel Kant and Martin Heidegger.
openaire +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Agency From A Stone: Shelley’s Posthumanist Experiments In Mont Blanc [PDF]
, 2016 This article reads Shelley’s ‘Mont Blanc’ as an extended exploration into possible modes of relationship linking the human mind to the material world.
Bolton, Betsy
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Halfway to paradise: documenting people and place, fictional constructs and considerations for post-documentary [PDF]
Dr Deverell explored the potential for video art to move past documentary into post-documentary. The research considered how established conventions in documentary practice are being contested and expanded with the growing dispersal and dissipation of ...
Deverell, K
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